Leptin regulates bone formation via the sympathetic nervous system.
By S. Takeda, Florent Elefteriou, R. Levasseur, Xiuyun Liu, Liping Zhao, K. Parker, D. Armstrong, P. Ducy, G. Karsenty. Cell, 2002
1,715 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/16219dcb752c9c96be878ebcf44877309b56c551
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In Endocrine and Autonomic Systems
In Physiology
Citations in the corpus
- Leptin regulation of bone mass, appetite and energy expenditure relies on its ability to inhibit serotonin synthesis in the brainstem (2009, neutral): “We removed one copy of this gene because Adrb2 is the only adrenergic receptor expressed in osteoblasts (Takeda et al., 2002).”
- Relationship of obesity with osteoporosis. (2007, background): “(32), however, reported that leptin may decrease bone formation via the sympathetic nervous system, indicating that the effect of leptin on bone mass is complex (33).”
- Control of osteoblast function and regulation of bone mass (2003, background): “Moreover, no similar findings were observed in mice with mutations in the α-melanocyte-stimulating hormone (α-MSH)/agouti/melanocortin-4 (MC-4)-receptor signalling pathway or the cocaine- and amphetamine-regulated transcript (CART) pathway, all of which are involved in the anorexigenic action of lep”
- PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors (2004, neutral): “osteogenic (30), whereas leptin is antiosteogenic (11, 13, 31), nei-”
- Leptin regulation of bone resorption by the sympathetic nervous system and CART (2005, background): “Sympathetic signalling via β2-adrenergic receptors (Adrb2) present on osteoblasts controls bone formation downstream of lepti”
- Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. (2015, background): “Furthermore, leptin exerts anti-osteogenic effects via sympathetic nervous activation in the hypothalamus [129].”
- Skeletal remodeling in health and disease (2007, background): “One of the most interesting revelations of the past decade has been the demonstration that the CNS directly regulates bone mas”
- Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. (2006, positive): “LEPRs in the VMH have previously been implicated in regulation of bone metabolism by leptin ( Takeda et al., 2002 ).”