Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis.

By Andrew J. Ewald, A. Brenot, Myhanh Duong, B. S. Chan, Zena Werb. Developmental Cell, 2008

639 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/35534ca9b9dfb0eef0772bb9e9a0c85a361c1593

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Pengfei Lu
2. Valerie M. Weaver
3. Zena Werb
4. M. Egeblad
5. E. Nakasone
6. A. Ridley
7. Andrew J. Ewald
8. D. Butcher

In Molecular Biology

1. Pengfei Lu
2. Zena Werb
3. Valerie M. Weaver
4. E. Nakasone
5. M. Egeblad
6. J. Massagué
7. Andrew J. Ewald
8. D. Nguyen

In Oncology

1. Pengfei Lu
2. Zena Werb
3. M. Egeblad
4. E. Nakasone
5. Valerie M. Weaver
6. J. Massagué
7. Andrew J. Ewald
8. D. Nguyen

Citations in the corpus

• Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development (2010, background): “To date there have been no detailed studies on dynamic cell rearrangements in these buds as with ureter bud (Costantini, 2006) and mammary gland epithelium (Ewald et al., 2008).”
• Mechanics, malignancy, and metastasis: The force journey of a tumor cell (2009, background): “These force interactions play similar roles in vertebrate embryogenesis [14] and the development of specific organ systems; for example, pharmacologic disruption of cellular contractility interferes with lung branching morphogenesis [15].”
• Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression (2010, background): “Collective migration has been identified as a critical cellular process particularly during mammary gland branching morphogenesis [16], intestinal epithelial differentiation [17] and wound healing [18].”
• Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program (2013, background): “The challenge of transitioning to a motile phenotype is particularly acute in mammary luminal epithelial cells, as these cells are normally connected by extensive intercellular junctions and display less spontaneous motility than myoepithelial cells in real-time analyses (Ewald et al., 2008).”
• Life at the leading edge. (2011, background): “Similarly, duct initiation in mammary epithelial morphogenesis requires Rac (Ewald et al., 2008), and Drosophila epithelial border cells extend long Rac-driven protrusions in order to migrate as a group between egg chamber cells toward the oocyte (Friedl and Gilmour, 2009).”
• Tumors as organs: complex tissues that interface with the entire organism (2010, positive): “Though tumors are quite different from normal quiescent tissues, the multilayered epithelium with poor polarity seen in early mammary tumors resembles the actively proliferating and invading epithelium of the terminal end buds of the developing mammary gland (Ewald et al., 2008).”
• A tense situation: forcing tumour progression (2009, background): “In multicellular tissues increased cell contractility can destabilize cell–cell adhesions and promote cell invasion to facilitate wound healing or drive MMP-dependent branching morphogenesi”
• In vitro cell migration and invasion assays. (2013, background): “Alternatively, collective migration happens in 3D as branches (mammary gland [28]), tubes (vascular sprouting [29]), strands or clusters (lateral line migration in fish [30]) or cancer cell invasion [31,32]).”
• Dynamic interplay between the collagen scaffold and tumor evolution (2010, background): “For example, the epithelial migration and invasion occurring in mammary carcinomas are morphologically and molecularly similar to epithelial branching morphogenesis in mammary gland development [2,3].”
• From cells to organs: building polarized tissue (2008, background): “For example, budding of the mammary gland tubular tree has recently been shown to involve an intermediate step whereby the buds are filled with multilayered cell”
• Metastasis: from dissemination to organ-specific colonization (2009, background): “In the mammary gland, the invasive and migratory mechanisms that underlie the branching morphogenesis of normal epithelial cells also regulate the formation of mammary hyperplasi”
• Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, neutral): “In a second type of collective invasion, a blunt bud-like tip protrudes along tissue space consisting of multiple cells that variably change position, lacking defined leader cells (Ewald et al., 2008); this type of invasion occurs preferentially in soft tissues and cells of strong epithelial polarit”
• Extracellular Matrix Degradation and Remodeling in Development and Disease (2011, background): “Specifically, cells in the duct are much less motile and proliferate less frequently than do tip cells (Shakya et al. 2005; Ewald et al. 2008; Lu et al. 2008a).”