Life at the leading edge.

By A. Ridley. Cell, 2011

957 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/2cfbf6485431f4ac18325706d012d0aca1676ce4

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In Cell Biology

1. Debashish Chowdhury
2. Ulrich S. Schwarz
3. Shmuel Safran
4. R. G. Hodge
5. A. Ridley

In Immunology and Allergy

1. Debashish Chowdhury
2. Shmuel Safran
3. Ulrich S. Schwarz
4. R. G. Hodge
5. A. Ridley

Citations in the corpus

• Regulating Rho GTPases and their regulators (2016, background): “Consequently, TNS3–PI3K localizes to the leading edge of migrating cells to promote RAC1 signalling and lamelli podium formation, presumably through PI3K– phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3)mediated recruitment of RAC GEFs112.”
• Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective (2012, background): “The actin-based protrusions of eukaryotic cells [1006, 1007, 1008, 1009, 1010, 1011, 1012, 1013, 1014, 1015, 1016, 1017, 1018, 1019, 1020, 1021, 1022].”
• Dynamic EMT: a multi‐tool for tumor progression (2021, neutral): “In BRAF-mutant melanoma, ZEB1 is sufficient and only partly compensated by TWIST to promote an undifferentiated p75 high neural crest stem cell-like state that is characterized by resistance to MAPK and BRAF inhibitors (Richard et al , 2016; Shaffer et al , 2017; Rambow et al , 2018).”
• Physics of adherent cells (2013, background): “Lamellipodia grow through the elementary processes of actin filament polymerization, branching, capping and crosslinking (Pollard and Borisy, 2003; Pollard and Cooper, 2009; Ridley, 2011), which have been extensively modeled (Mogilner, 2006; Pollard and Berro, 2009).”
• Actin dynamics, architecture, and mechanics in cell motility. (2014, background): “N-WASP has been exclusively associated with filopodia formation and specialized protrusions of invasive cancer cells called invadopodia (258, 274).”