Anatomical basis of tolerance and immunity to intestinal antigens

By A. Mowat. Nature reviews. Immunology, 2003

1,487 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/352518be628abd337f4a7320793c896bacfaeed2

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Citations in the corpus

Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk (2022, background): “As regards the respiratory system, inhaled MPs likely penetrate the lower respiratory tract, characterised by a thin mucus layer, and spread into the bloodstream after cellular uptake or paracellular diffusion [45].”
Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells (2006, background): “This phenomenon is known as oral tolerance and represents a key feature of intestinal immunity (1).”
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses (2007, background): “, are located in the lamina propria, Peyer's patches and mesenteric lymph nodes, and are among the first cells to sense and respond to endogenous bacterial flor”
Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. (2011, background): “DISCUSSION Oral tolerance is envisioned as a multifactorial process that involves deletion or anergy of reactive T cells and the induction of regulatory T cells (Dubois et al., 2009; Faria and Weiner, 2005; Goubier et al., 2008; Mowat, 2003).”
Probiotics and immunity (2009, background): “tory functions and thereby induce oral tolerance.(6,14) One of the most extensively studied mechanisms for the induction of regulatory T cells by DCs is the release of IL-10 or transforming growth factor (TGF)-β, resulting in Tr1 and Th3 cells regulatory T cells that act through the secretion of IL-”
Update on food allergy. (2004, background): “It has been suggested that T cells primed in the local mucosal environment lead to tolerance induction, whereas T cells primed in the mesenteric lymph nodes, either from antigen reaching the node in the lymph or carried there by circulating dendritic cells, differentiate and travel to the mucosa, wh”
Mucosal immunity and vaccines (2005, background): “It is comprised of anatomically defined lymphoid microcompartments such as the Peyer patches, the mesenteric lymph nodes, the appendix and solitary follicles in the intestine, and the tonsils and adenoids at the entrance of the aerodigestive tract, which serve as the principal mucosal inductive site”
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age (2009, background): “The major functions attributed to the microbiota present in the gut begin to manifest at the end of the second year of life and comprise: i) nutrients absorption and food fermentation [10], ii) stimulation of the host immune system [11] and iii) barrier effects against pathogens [12].”
The light and dark sides of intestinal intraepithelial lymphocytes (2011, positive): “In contrast to the natural IELs, induced IELs acquire an activated phenotype in response to cognate antigens encountered in the peripher”
Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota (2012, background): “Primed lymphocytes expressing a4b7 and CCR9 in secondary gut lymphoid organs enter the bloodstream and ultimately exit into gut tissue through vessels in the small intestinal LP where MAdCAM and CCL25—ligands of a4b7 and CCR9, respectively—are expressed (Mowat, 2003).”
Oral tolerance (2011, background): “It has also become clear that the GALT is a rich and complex immune network that has evolved to induce immunologic tolerance and Tregs (5).”
Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells (2005, result): “Our results support the hypothesis that in steady-state conditions, mucosal tissues favor the induction of mucosal immune responses, including the polarization of T cells toward a T H 2 phenotype and the production of Ig”