Cytokine control of memory T-cell development and survival

By K. Schluns, L. Lefrançois. Nature reviews. Immunology, 2003

1,046 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/34a11bbb0c9fd95e9e74162b1ae06b139d1ea949

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In Immunology

1. Rafi Ahmed
2. M. Bevan
3. E. Wherry
4. S. Kaech
5. F. Sallusto
6. A. Lanzavecchia
7. Joseph C. Sun
8. V. Badovinac

Citations in the corpus

• Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1 (2010, background): “By the time when memory T cells are generated in response to acute viral or bacterial infection, inflammatory cytokines produced during early immune responses have subsided, and it has been demonstrated that persistence of memory CD8 T cells does not depend on signaling from MHC class I ligands but ”
• NK cell development, homeostasis and function: parallels with CD8+ T cells (2011, background): “IL-7 and IL-15 then protect memory precursor cells from cell death during the contraction phase of the T cell respons”
• CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection (2004, background): “It has also been suggested that signals given during the contraction or maintenance phases regulate homeostasis of the memory populatio”
• Signals required for programming effector and memory development by CD8+ T cells (2006, background): “Introduction Upon exiting the thymus, mature naı̈ve CD8+ T cells circulate in the blood and lymphoid organs, with signals from interleukin-7 (IL-7) and IL-15 receptors promoting their survival, and the cells lack most of the effector functions characteristic of activated cytotoxic T lymphocytes (CTL”
• Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells (2003, background): “Because IL-15 is also involved in memory cell development and maintenanc”
• L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity (2016, background): “Subsequently, they divide rapidly and differentiate into effector T cells that produce inflammatory cytokines, such as IFN-g, and into memory T cells that survive through homeostatic mechanisms (Schluns and Lefrançois, 2003; Surh et al., 2006).”
• TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance (2005, neutral): “Since neutralization of TGF-β in vivo does not alter FasL expression on antigen-specific CTLs, we conclude that Fas-FasL pathway does not play an essential role in this in vivo tumor clearance model.”
• Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function (2005, background): “IL-15 potently promotes proliferation of memory CD8 � T cells (8, 11 , 12); the major subset of memory (IL- 2R � high CD44 high ) CD8 � T cells depends on”
• Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. (2007, background): “Although KLRG1hi IL-7Rlo cells were relatively short-lived, we examined if IL-15 sustains their survival because they cannot receive IL-7 signals and together, IL-7 and IL-15 promote memory CD8 T cell longevity and self-renewal (Hand et al., 2007; Schluns and Lefrancois, 2003).”