Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.

By Nikhil S. Joshi, W. Cui, A. Chandele, H. Lee, David Urso, J. Hagman, L. Gapin, S. Kaech. Immunity, 2007

1,942 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/000ddb8eb1e823c3d275856ca8568ef899d1a44e

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In Immunology

1. Rafi Ahmed
2. E. Wherry
3. M. Bevan
4. F. Sallusto
5. A. Lanzavecchia
6. S. Kaech
7. K. Araki
8. V. Badovinac

Citations in the corpus

• CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. (2019, background): “In acute infections, loss of T-bet compromises the KLRG-1+ population but KLRG-1− Teff cells form and Tmem cells are generated (139, 252, 259).”
• Differentiation of Effector CD4 T Cell Populations (2010, neutral): “Furthermore, T-bet suppresses IL-7Rα expression and thus affects the generation of central memory CD8 T cells (75, 76).”
• From Vaccines to Memory and Back (2010, background): “In mice, the precursors of memory CD8+ T cells could be identified as IL-7Rhi cells, whereas the more abundant KLRG1hi (killer cell lectin-like receptor G1) cells were shown to represent short-lived effector cells (Joshi et al., 2007; Kaech et al., 2003; Sarkar et al., 2008).”
• Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, background): “…to play a key role in some cell-fate decisions in the developing T cell response by altering the distribution of effector T cells that have memory T cell potential (i.e., MPECs) versus terminally differentiated cells (i.e., SLECs) (Badovinac et al., 2005; Joshi et al., 2007; Pearce and Shen, 2007).”
• Successful anti-PD-1 cancer immunotherapy requires T cell-dendritic cell crosstalk involving the cytokines IFN-γ and IL-12 (2018, positive): “Indeed, IL-12 may activate T-bet (Joshi et al., 2007; Szabo et al., 2000) and in doing so subvert exhaustion phenotypes (Kao et al., 2011).”
• CD8+ T Cells: Foot Soldiers of the Immune System (2011, positive): “Mechanistically, IL-12 promotes effector CD8 + T cell differentiation through the induction of T-bet (Joshi et al., 2007; Takemoto et al., 2006) via an mTOR-dependent pathway (Rao et al., 2010).”