The extracellular matrix modulates the hallmarks of cancer

By Michael W. Pickup, J. Mouw, Valerie M. Weaver. EMBO Reports, 2014

1,724 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/5b98c8163a4468b214440830a1980e98724717ac

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Lance L. Munn
2. Rakesh K. Jain
3. Hadi Tavakoli Nia
4. C. Roma-Rodrigues
5. Alexandra R. Fernandes
6. R. Mendes
7. Pedro Viana Baptista
8. J. Hong

In Cell Biology

1. Rakesh K. Jain
2. Alexandra Naba
3. Steven A. Carr
4. Karl R. Clauser
5. R. Hynes
6. Peter Friedl
7. M. Humphries
8. Stephanie Alexander

In Oncology

1. Rakesh K. Jain
2. Lance L. Munn
3. C. Roma-Rodrigues
4. Alexandra R. Fernandes
5. J. Hong
6. R. Mendes
7. M. Park
8. Alexandra Naba

Citations in the corpus

• Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches (2016, background): “NF-κB contributes to extracellular matrix destruction by cancer cells [48,49].”
• Targeting Tumor Microenvironment for Cancer Therapy (2019, background): “Under normal conditions, the ECM is divided into the interstitial matrix, which involves the stromal cells forming the connective tissue, and the basal membrane, a specialized layer that in epithelial tissue divides epithelial and endothelial cells from the underlying stroma [14,24].”
• The Extracellular Matrix: Tools and Insights for the “Omics” Era (2015, background): “Recent studies from us and others have revealed that the ECM plays a functional role in tumor progression and dissemination [13,14].”
• Physical traits of cancer (2020, background): “Today, there are numerous studies showing how thematerial properties—in particular, the stiffness of themicroenvironment—are central to many traits of cancer (79), including proliferation (80, 81), angiogenesis (82), metabolism (83), invasion (84–86), andmigration andmetastasis (87–89) (Fig.”
• Mutant p53 as a guardian of the cancer cell (2018, neutral): “cytoskeleton, which in turn favors tumor cell survival, proliferation and tumor progression [17].”
• Extracellular matrix (ECM) stiffness and degradation as cancer drivers (2018, background): “These two processes are related with one another.(53) Therefore, maintaining ECM contents in homeostasis would be a promising approach for cancer therapy.”