The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo.

By J. Blagih, F. Coulombe, E. Vincent, Fanny Dupuy, Gabriela Galicia-Vázquez, E. Yurchenko, T. Raissi, G. V. D. van der Windt, B. Viollet, Erika L. Pearce and 5 more. Immunity, 2015

604 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/df9fb51130db62a5ef2795d910b7bc14592cd4bd

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Citations in the corpus

Unraveling the Complex Interplay Between T Cell Metabolism and Function (2018, background): “Mice with T cells deficient for AMPK exhibit decreased Te cell responses during primary infection and reduced inflammation during T cell–mediated colitis (60).”
T cell metabolism drives immunity (2015, background): “In addition, AMPK allows for effector T cells to metabolically adapt during nutrient stress and modulates T cell effector function through suppression of mTOR (Tamás et al., 2006; MacIver et al., 2011; Blagih et al., 2015).”
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity (2016, background): “…(OXPHOS) for their energy supply, activated T cells consume large amounts of glucose, amino acids, and fatty acids and adjust their metabolic pathways toward increased glycolytic and glutaminolytic activity (Blagih et al., 2015; Rolf et al., 2013; Sinclair et al., 2013; Wang et al., 2011).”
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses (2015, background): “Metabolic flexibility allows activated T cells to adapt to changes in glucose availability by utilizing alternative substrates 1226 Cell 162, 1217–1228, September 10, 2015 ª2015 Elsevier Inc. for energy production (Blagih et al., 2015; Frauwirth et al., 2002).”
Glutaminolysis: A Hallmark of Cancer Metabolism. (2017, background): “F or p er so na l u se o nl y. lncRNA: long noncoding RNA PCGEM1: prostate cancer gene expression marker 1 RNF5: ubiquitin ligase ring finger protein ER: endoplasmic reticulum IL-4: interleukin-4 AMPK: AMP-activated protein kinase HIF1: hypoxia-inducible factor 1 OGDH: oxoglutarate dehydrogenase CPS”
Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy. (2020, background): “However, AMPK-deficient T cells also became more sensitive to stress and apoptosis, as shown by their decreased efficacy in vivo in settings such as lung inflammation (Blagih et al., 2015).”