Fiber-optic fluorescence imaging

By B. Flusberg, E. Cocker, W. Piyawattanametha, Juergen C. Jung, Eunice L M Cheung, Mark J. Schnitzer. Nature Methods, 2005

720 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Biophysics

View Paper: https://www.semanticscholar.org/paper/336657bbff4191e25fc24799f30d2474ebbfaac2

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Citations in the corpus

Imaging in the era of molecular oncology (2008, background): “Miniaturized systems are available for experimental work, and several other systems are being adapted for endoscopic clinical imagin”
Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy (2011, positive): “Use of these modalities, including in humans 17,18 , has enabled cellular imaging in the cochlea, hippocampus, thalamus, deep neocortex, digestive tract, and muscles, albeit only in acute studies 15 .”
Genetic dissection of neural circuits. (2008, neutral): “The confluence of advances in genetically encoded indicators, deep-tissuemicroscopy (reviewed in Flusberg et al., 2005; Helmchen and Denk, 2005; Svoboda and Yasuda, 2006), and genetic targeting techniques (Section 2) will allow the imaging of activity in genetically defined neuronal ensembles in…”
Closed-loop and activity-guided optogenetic control. (2015, positive): “…recording with fiber photometry, or with image-forming devices such as fiber bundles (Szabo et al., 2014) or implantable GRIN optics (Ghosh et al., 2011; Flusberg et al., 2005) that can allow near-cellular resolution imaging with optogenetic stimulation (Figure 4G; right middle and right panels).”
Experience-dependent structural synaptic plasticity in the mammalian brain (2009, methodology): “High-resolution imaging in deep brain regions, like the hippocampus, requires invasive surgical method”
Learning to see through multimode fibers (2018, background): “Optical fibers are prominently used in telecommunications [1] and endoscopy for medical diagnosis [2].”
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. (2007, methodology): “…the use of ChR2 methodology alongside, or in conjunction with, twophoton laser scanning microscopy for light activation, in vivo fiber optics (Flusberg et al., 2005a; Piyawattanametha et al., 2006), other heterologous stimulation methods based on receptor-ligand binding (Lima and Miesenbock,…”
Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits (2006, background): “One compact and lightweight (3.9 g) fiber-optic two-photon microendoscope for portable brain imaging relies on a single optical fiber for light delivery and another for fluorescence collection, allowing in vivo imaging with 1.2 m lateral resolution (Flusberg et al., 2005a).”
Fluorescence imaging in vivo: recent advances. (2007, background): “25– 1 mm in diameter) that are minimally invasively inserted into solid tissues to achieve high-resolution imaging deep within tissues [57].”