Closed-loop and activity-guided optogenetic control.
By Logan Grosenick, James H. Marshel, Karl Deisseroth. Neuron, 2015
377 citations recorded by the source corpus.
Advances in optical manipulation and observation of neural activity have set the stage for widespread implementation of closed-loop and activity-guided optical control of neural circuit dynamics. Closing the loop optogenetically (i.e., basing optogenetic stimulation on simultaneously observed dynamics in a principled way) is a powerful strategy for causal investigation of neural circuitry. In particular, observing and feeding back the effects of circuit interventions on physiologically relevant timescales is valuable for directly testing whether inferred models of dynamics, connectivity, and causation are accurate in vivo. Here we highlight technical and theoretical foundations as well as recent advances and opportunities in this area, and we review in detail the known caveats and limitations of optogenetic experimentation in the context of addressing these challenges with closed-loop optogenetic control in behaving animals.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/1386d5bcaa1f148178014d934fc99c8d7447a56e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
Citations in the corpus
- Attractor and integrator networks in the brain (2021, positive): “On the experimental side, tools for high-resolution population-level neural recrdings and perturbation across multiple brain areas [266, 82, 83] let us peer further and deeper than ever.”
- Two’s company, three (or more) is a simplex (2016, background): “For example, with new optogenetics capabilities, we can stimulate single neurons or specific groups of neurons to control their function (Grosenick et al, 2015).”