Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content.

By S. Pece, D. Tosoni, S. Confalonieri, G. Mazzarol, M. Vecchi, S. Ronzoni, L. Bernard, G. Viale, Pier Giuseppe Pelicci, P. P. Di Fiore. Cell, 2010

946 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/31f97b911b642ae0ac677a9348de900fd7a0762a

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Citations in the corpus

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells (2014, background): “BM2 cells were labeled with the lipophilic dye PKH26, which is retained in dormant or slow-cycling cells in culture (23).”
Interactions between cancer stem cells and their niche govern metastatic colonization (2011, methodology): “Growth under conditions of ultralow attachment has been used to study CSCs in vitro”
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. (2011, background): “Thus, MII and MIV cells are endowed with significantly different self-renewal and tumorigenic potential, recapitulating the differences in CSC representation previously reported for G1 versus G3 tumors (Pece et al., 2010).”
CLONAL EVOLUTION IN CANCER (2012, background): “The frequency of cancer stem cells could then increase from low to very high frequency as the disease progresse”
GSVA: gene set variation analysis for microarray and RNA-Seq data (2013, methodology): “GSE methods have been successfully applied in many experimental conditions to interpret the pathway architecture of biological states including cancer [13, 14], metabolic disease [15], and development [16].”
The cancer stem cell: premises, promises and challenges (2011, neutral): “When applied to breast cancers, this gene signature correlated with CSC behavio”
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. (2010, background): “EMT in epithelial tumors is associated with increased invasiveness, therapeutic resistance, and potentially, the generation of cells with cancer stem cell-like properties (Polyak and Weinberg, 2009).”
Evolution of the cancer stem cell model. (2014, background): “Recently, stemness signatures have been developed from normal stem cells in solid tissues including the intestine and breast (Merlos-Sua´rez et al., 2011; Pece et al., 2010).”
The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, neutral): “Dormancy is a critical issue for tumor recurrence and metastatic spread after long lag periods in many cancers, including breast, melanoma, and leukemia (Pece et al., 2010; Roesch et al., 2010; Saito et al., 2010).”
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. (2011, background): “A recent work by Di Fiore and colleagues correlates higher grading in breast cancers with higher frequencies of cancer cells expressing a breast stem cell-like phenotype (Pece et al., 2010).”