Interactions between cancer stem cells and their niche govern metastatic colonization

By I. Malanchi, A. Santamaria-Martínez, Evelyn Susanto, Hong Peng, H. Lehr, J. Delaloye, J. Huelsken. Nature, 2011

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Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19 (2018, background): “As is well known, periostin, expressed by fibroblasts in normal tissue and primary tumors, promotes the metastasis of breast tumors by enhancing breast CSC maintenance [76].”
Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “In contrast, TNC and POSTN promote metastatic reactivation by activating Wnt and Notch signaling (O’Connell et al., 2011; Oskarsson et al., 2011; Malanchi et al., 2011).”
Epithelial-Mesenchymal Plasticity: A central regulator of cancer progression (2015, background): “Thus, the quasi-mesenchymal cells that serve as the founders of metastatic colonies must be able to spawn large numbers of epithelial progeny to recreate the hierarchical relationships of CSCs and non-CSC that previously operated within the corresponding primary tumors (Malanchi et al., 2012; Thiery”