BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.

By G. Molyneux, F. Geyer, Fiona-Ann Magnay, Afshan Mccarthy, H. Kendrick, R. Natrajan, A. Mackay, A. Grigoriadis, Andrew Tutt, Alan Ashworth and 2 more. Cell Stem Cell, 2010

792 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8f9ac3d69bf6cdd754871e7d4619bfb1c05186a2

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Citations in the corpus

Deconstructing the molecular portraits of breast cancer (2010, background): “…with recent data coming from a genetically engineered mouse models study that deleted BRCA1 in the mouse mammary epithelial luminal progenitors (Molyneux et al., 2010), suggest that the potential cell of origin of sporadic and BRCA1-mutated Basal-like breast cancers could be the luminal…”
Cells of origin in cancer (2011, background): “Indeed, inactivation of Brca1 (and p53 ) in either luminal or basal cells of the mouse mammary gland showed that only the luminal cell population initiated basal-like cancers reminiscent of those arising in BRCA1 -mutation carrier”
Risk Factors and Preventions of Breast Cancer (2017, background): “bCSCs are more likely to originate from luminal epithelial progenitors rather than from basal stem cells [17].”
Camera: a competitive gene set test accounting for inter-gene correlation (2012, result): “This confirmed the strong presence of the luminal progenitor signature in the basal-like tumors as opposed to the other tumor subtypes (Table 4), confirming luminal progenitors as the likely cell of origin for basal cancers (31,38).”
Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts (2013, background): “It was previously suggested that basal and BRCA1-associated breast carcinomas originate from EPCAM+CD49f+ luminal progenitor cells (Proia et al., 2011; Molyneux et al., 2010).”
Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists (2011, result): “57 and confirmed by the results of conditional mouse models”
Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program (2013, background): “Experimental models suggest that basal breast cancers arise from luminal progenitors and that mutations in genetic drivers of breast cancer, such as BRCA1, can shift luminal progenitors toward basal differentiation (Lim et al., 2009; Molyneux et al., 2010).”
EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, neutral): “(Gupta et al., 2005; Ince et al., 2007; Lim et al., 2009; Molyneux et al., 2010; Proia et al., 2011).”
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs (2011, background): “, which is the presumptive origin of basal breast carcinoma”
Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis (2018, background): “Cells with a potential for phenotypic plasticity do not necessarily reflect histology in tumor phenotypes.(229)”