Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

By B. Wolozin, Wendy Kellman, Paul Ruosseau, G. Celesia, G. Siegel. Archives of Neurology, 2000

1,486 citations recorded by the source corpus.

Subfields: Physiology, Psychiatry and Mental health, Surgery

View Paper: https://www.semanticscholar.org/paper/31c0c7de23b91151e3dfe4c8180e800dd647d8d3

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Citations in the corpus

Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal Published, JLR Papers in Press, May 16, 2004. DOI 10.1194/jlr.R400004-JLR200 (2004, background): “ment of older individuals with pharmaceutical agents that decreased the plasma cholesterol concentration appeared to be associated with a lower incidence of such dementias (11, 12).”
Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference (2012, background): “…that simvastatin was associated with a strong reduction in the incidence of dementia, Alzheimer’s disease (AD) and Parkinson’s disease (PD) [43,44]; several studies proved that estrogen treatment was effective in many neurodegenerative disease models [41,45]; and statins were also found to…”
Mitochondrial Glutathione, a Key Survival Antioxidant (2009, background): “In addition, epidemiologic observations identified hypercholesterolemia in midlife as a major risk factor for AD (3, 145).”
The changing faces of glutathione, a cellular protagonist. (2003, background): “High cholesterol levels correlated with Aβ deposition and the risk of developing AD, while patients taking the cholesterol-lowering drug statins were found to have a lower incidence of the disease (Notkola et al., 1998; Wolozin et al., 2000).”
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts (2003, background): “Th e Jo ur na l o f C el l B io lo gy The Rockefeller University Press, 0021-9525/2003/01/113/11 $8.00 The Journal of Cell Biology, Volume 160, Number 1, January 6, 2003 113–123 http://www.jcb.org/cgi/doi/10.1083/jcb.200207113 JCB Article 113”
Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline (2007, background): “Statins used for the treatment of hypercholesterolaemia were found to decrease the prevalence of AD in two studies with retrospective or cross-sectional analysis [187,188].”