Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
By Z. Allakhverdi, M. Comeau, H. Jessup, B. P. Yoon, A. Brewer, S. Chartier, Nicole Paquette, Steven F. Ziegler, M. Sarfati, G. Delespesse. Journal of Experimental Medicine, 2007
788 citations recorded by the source corpus.
Compelling evidence suggests that the epithelial cell–derived cytokine thymic stromal lymphopoietin (TSLP) may initiate asthma or atopic dermatitis through a dendritic cell–mediated T helper (Th)2 response. Here, we describe how TSLP might initiate and aggravate allergic inflammation in the absence of T lymphocytes and immunoglobulin E antibodies via the innate immune system. We show that TSLP, synergistically with interleukin 1 and tumor necrosis factor, stimulates the production of high levels of Th2 cytokines by human mast cells (MCs). We next report that TSLP is released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines. Direct epithelial cell–mediated, TSLP-dependent activation of MCs may play a central role in “intrinsic” forms of atopic diseases and explain the aggravating role of infection and scratching in these diseases.
Subfields: Dermatology, Immunology and Allergy, Physiology
View Paper: https://www.semanticscholar.org/paper/f72802dcebf912673e4c1dec850f7e4c89601eae
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Dermatology
In Immunology and Allergy
In Physiology
Citations in the corpus
- The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’? (2008, background): “IL-33 could act alone or in concert with other mediators, such as thymic stromal lymphopoietin (TSLP), which is also expressed by inflamed skin and tonsillar crypt epithelium, and can be released by epithelial cells in response to trauma or infection [5,29,30].”
- Immunology of asthma and chronic obstructive pulmonary disease (2008, background): “The cytokine thymic stromal lymphopoietin ( TSLP ), which is secreted in large amounts by epithelial cells and mast cells of asthmatic patient”
- The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma (2014, background): “aureus in AD skin further stimulate keratinocytes to produce TSLP and induce polyclonal activation of T cells via binding directly to the common variable β (vβ) chains of T-cell receptors [83-85], which results in exaggerated Th2 inflammatory responses leading to worsening AD, and this can also prom”
- Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut (2008, background): “Tslp mRNA is constitutively expressed by IECs, although its expression by mucosal epithelial cells can be upregulated in response to a range of stimuli, including infection, inflammation and tissue injur”
- How are TH2-type immune responses initiated and amplified? (2010, background): “TSLP produced by epithelial cells also activates mast cell”
- Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma (2008, background): “In addition to its effects on DCs, TSLP can also activate human mast cells to produce T H 2-cell-associated effector cytokines in the absence of T cells or IgE crosslinkin”