Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.

By A. Dinkova-Kostova, K. Liby, K. Stephenson, W. Holtzclaw, Xiangqun Gao, N. Suh, Charlotte R. Williams, R. Risingsong, T. Honda, G. Gribble and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2005

601 citations recorded by the source corpus.

Subfields: Molecular Biology, Toxicology

View Paper: https://www.semanticscholar.org/paper/30bb10e4843a4d67697a5561e051251874ee6797

How researchers see this paper

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In Molecular Biology

1. Q. Ma
2. Liam Baird
3. A. Dinkova-Kostova
4. M. Araya
5. E. Jeffery
6. M. Sporn
7. K. Liby
8. E. Panieri

Citations in the corpus

• Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer (2007, background): “Structure-activity analysis shows that α,β-unsaturated carbonyl groups at key positions on rings A and C are essential for the striking anti-inflammatory potency of S”
• Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies (2006, unknown): “Cancer Prevention Agents: Dinkova-Kostova et al. (2005), triterpenoid analogs.”
• Role of nrf2 in oxidative stress and toxicity. (2013, background): “In addition to being potent inducers of ARE genes and anticancer agents, cyano enone inducers exhibit strong anti-inflammatory, hypoglycemic, antihyperlipidemic, antiproliferative, and proapoptotic activities (97, 157).”
• The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “Indeed, Nrf2 inducers also have anti-inflammatory effects, and furthermore, there is a linear correlation between these two activities over a very broad range (six orders of magnitude) of concentrations (Dinkova-Kostova et al. 2005b; Liu et al. 2008).”
• Physiological effects of broccoli consumption (2008, background): “Dinkova-Kostova and colleagues have identified an inverse relationship between upregulation of NQO1 and suppression of COX-2 and iNOS upregulation by c-interferon, strengthening the suggestion that quinone reductase plays an integral role in prevention of inflammation (Dinkova-Kostova et al. 2005).”
• Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, unknown): “Indeed, there is now compelling experimental evidence that exogenous and endogenous inducers chemically modify specific and highly reactive cysteine residues of Keap1, which, in addition to being a repressor for Nrf2, also functions as the intracellular sensor for inducers (157, 216).”
• An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation (2020, background): “Another report showed that the induction of NQO1 by several synthetic triterpenoids resulted in the decreased expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) in Hepa1c1c7 murine hepatoma cells, an effect that was strictly Nrf2-dependent and related to the direct interaction”