Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

By G. Nicolas, M. Bennoun, A. Porteu, S. Mativet, C. Beaumont, B. Grandchamp, M. Sirito, M. Sawadogo, A. Kahn, S. Vaulont. Proceedings of the National Academy of Sciences of the United States of America, 2002

948 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/2ff6d61f1830769af0a201a3ebcd4e7b0d461d9d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. T. Ganz
2. E. Nemeth
3. V. Haase
4. S. Rivera
5. B. K. Pedersen
6. C. Keller
7. V. Gabayan
8. S. Taudorf

In Hematology

1. T. Ganz
2. E. Nemeth
3. V. Haase
4. S. Rivera
5. B. K. Pedersen
6. C. Keller
7. V. Gabayan
8. S. Taudorf

In Nutrition and Dietetics

1. T. Ganz
2. E. Nemeth
3. B. K. Pedersen

Citations in the corpus

• IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. (2004, positive): “Recent studies indicate that hepcidin (in mice, hepcidin-1) inhibits intestinal iron absorption (4, 5), placental iron transport (4), and release of recycled iron from macrophages (5), effectively decreasing the delivery of iron to maturing erythrocytes in the bone marrow.”
• Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). (2007, background): “Genetic studies in mice lacking or overexpressing hepcidin suggest that this peptide inhibits both iron absorption in the small intestine and the release of recycled iron from macrophages (2, 3).”
• Immunoassay for human serum hepcidin. (2008, neutral): “0) Ferritin 109 (42-398) 39 (13-85) 118 (15-288) 46 (18-140)”
• The Role of Hepcidin in Iron Metabolism (2009, background): “Even though hepcidin is rapidly cleared from the plasma, the effect of a single dose was apparent for up to 72 h, likely because of the time required to resynthesize sufficient amounts of the hepcidin receptor, ferroportin.Chronic overexpression of hepcidin causes iron-restricted anemia in mice and ”
• The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. (2002, positive): “However, the hepc1 sequence is the most highly related to the human one, and we recently provided experimental data supporting a functional role for hepc1 in vivo (7).”
• The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. (2005, background): “An important clue came from the discovery of hepcidin, a circulating peptide that has profound effects on iron absorption and distribution (Nicolas et al., 2001, 2002).”