IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.

By E. Nemeth, S. Rivera, V. Gabayan, C. Keller, S. Taudorf, B. K. Pedersen, T. Ganz. Journal of Clinical Investigation, 2004

2,678 citations recorded by the source corpus.

Subfields: Hematology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/c79d89c626c9b8e68cb2d0a01ee3546117797367

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. T. Ganz
2. E. Nemeth
3. V. Haase
4. Kostas Pantopoulos
5. G. Papanikolaou
6. Tracey Rouault
7. S. Finotto
8. Markus F. Neurath

In Nutrition and Dietetics

1. T. Ganz
2. E. Nemeth
3. G. Papanikolaou
4. Tracey Rouault
5. Kostas Pantopoulos

Citations in the corpus

• Iron metabolism and toxicity. (2005, background): “Hepcidin expression is increased in inflammation (Nemeth et al., 2004) and secondary iron overload (Adamsky et al.”
• A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. (2005, background): “Additional factors/ conditions, including IL-6, c/EBP a , iron, hypoxia, and inflammation, also regulate hepcidin expression (Courselaud et al., 2002; Nemeth et al., 2004a).”
• IL-6 in inflammation, immunity, and disease. (2014, background): “As for serum iron, IL-6 induces hepcidin production, which blocks the action of iron transporter ferroportin 1 on gut and, thus, reduces serum iron levels (Nemeth et al. 2004).”
• Systemic iron homeostasis. (2013, background): “Subsequently, microbial molecules, the plant-derived inflammatory agent turpentine, and cytokines were shown to be potent inducers of hepcidin synthesis (162, 165, 168, 186).”
• Anemia of Inflammation (2014, positive): “The production of hepcidin by hepatocytes is in turn regulated by plasma and hepatic iron concentrations and inflammatory cytokines, chiefly IL-6.”
• IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial (2008, background): “24 IL-6 signalling activates the JAK–STAT pathway to stimulate the production of acute phase proteins, including CRP and hepcidin.”
• Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). (2007, background): “As Albumin-Cre/VHLflox/flox mice exhibit hepatic inflammation and steatosis (21) (Figure 2C), we examined levels of the proinflammatory cytokine IL-6, which is known to stimulate hepcidin expression and may contribute to the anemia of chronic inflammation (5).”