Intrinsic epithelial cells repair the kidney after injury.

By B. Humphreys, M. Valerius, Akio Kobayashi, Joshua W. Mugford, Savuth Soeung, Jeremy S. Duffield, Andrew P. McMahon, Joseph V. Bonventre. Cell Stem Cell, 2008

866 citations recorded by the source corpus.

Subfields: Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/2ff5a9e246f6607b01f20313719b1ce29bbdb54c

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Citations in the corpus

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury (2010, neutral): “2144" language="eng" relation="no"> The repair process after tissue injury involves a regeneration phase, in which injured cells are replaced by cells of the same lineag”
Cellular and molecular mechanisms in kidney fibrosis. (2014, neutral): “When the DNA recombinase enzyme Cre is expressed at the FOXD1 locus in mice, which also transgenically express a Cre-dependent reporter transgene, the reporter is permanently activated in all daughters of the progenitor cells, regardless of cell fate due to somatic DNA recombination (15, 29).”
Pathophysiology of Acute Kidney Injury (2012, neutral): “In both rats and mice, severe acute injury following ischemia or nephrotoxic insults results cellular proliferation as shown by 3Hthymidine (109, 110, 361) or BrdU incorporation (219, 325, 369, 370, 520) or by the expression of PCNA (360) or Ki67 antigen (481) usually apparent in less than 1 day fol”
Pathophysiology of ischemic acute kidney injury (2011, methodology): “With the use of genetic fate-mapping techniques and chimeric mice, Humphreys et al”
From cells to organs: building polarized tissue (2008, background): “In the case of the kidney, at least, this involves the local proliferation of epithelial cells, which replace their dead neighbours in denuded regions of the tubules through a process that appears to involve a pEM”
Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. (2011, background): “Based on this observation and on findings indicating that tubular repopulation after AKI depends on the reentry into cycle of renal tubular cells survived to injury [42,43], it has been suggested that MSCs may provide a paracrine support to kidney repair [41].”
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development (2008, background): “A recent analysis demonstrates that nephron repair in the adult occurs through an intratubular mechanism (Humphreys et al., 2008).”
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development (2010, positive): “Instead, adult renal epithe- lial cells retain the ability to dedifferentiate and repair the kidney following injury (Humphreys et al., 2008).”
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. (2010, methodology): “Antibody enhancement of RFP signal was performed as previously described and gave identical results in vivo to native RFP fluorescence (data not shown).(34) Confocal images were generated using a Nikon C1 D-Eclipse confocal microscope as previously described.”