Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development

By F. Costantini, Raphael Kopan. Developmental Cell, 2010

686 citations recorded by the source corpus.

Summary The two major components of the kidney, the collecting system and the nephron, have different developmental histories. The collecting system arises by the reiterated branching of a simple epithelial tube, while the nephron forms from a cloud of mesenchymal cells that coalesces into epithelial vesicles. Each develops into a morphologically complex and highly differentiated structure, and together they provide essential filtration and resorption functions. In this review we will consider their embryological origin, and the genes controlling their morphogenesis, patterning and differentiation, focusing on recent advances in several areas.

Subfields: Molecular Biology, Public Health, Environmental and Occupational Health, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/2bcefe8e1e9d66e69267232d5ed8e053a0875270

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Citations in the corpus

• Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. (2014, background): “…the MM and ureteric bud lineage segregate from one another have not been clarified, despite many reports showing the importance of various growth factors during kidney development (Costantini and Kopan, 2010; Fleming et al., 2013; Kim and Dressler, 2005; Moriya et al., 1993; Poladia et al., 2006).”