Neurogenesis in the adult brain: death of a dogma

By Charles G. Gross. Nature Reviews Neuroscience, 2000

799 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/2efa99c3b6fc6c5f185569c03acffdd9b9cc75ea

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Developmental Neuroscience

Citations in the corpus

Erythropoietin Regulates the In Vitro and In Vivo Production of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells (2001, background): “Although various pathologic and physiologic stimuli appear to regulate neurogenesis in the adult dentate gyrus (for review, see McEwen, 1999; Gross, 2000; Kempermann and Gage, 2000), much less is known about the NSC lineage and its role in olfactory neurogenesis.”
The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis. (2002, methodology): “It is believed that the application of this BrdU method contributed to the current acceptance of neurogenesis as a natural process in the brain of adult mammals (Gross, 2000).”
Enriched Odor Exposure Increases the Number of Newborn Neurons in the Adult Olfactory Bulb and Improves Odor Memory (2002, background): “The first region concerns the subgranular zone of the dentate gyrus in the hippocampus formation that gives rise to granule cells (for review, see Gage, 2000; Gross, 2000).”
Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus (2005, background): “Recently, it has been shown that new neurons are continuously added to the dentate gyrus (DG), a region of the hippocampal formation (Gross, 2000; Abrous et al., 2005).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “It is widely accepted that neurogenesis, a process whereby mature functionally integrated neurons are generated from progenitor cells, occurs exclusively in discrete, neurogenic regions of the adult mammalian brain (Gross, 2000).”
Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons (2007, background): “This dogma, restricting neurogenesis to a developmental phenomenon has, however, been challenged by the discovery that new neurons are created in specific regions of the adult mammalian brain [2,3].”
New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment (2005, background): “Functionally, these findings support one current view that newborn cells may increase the ability for future learning by providing more cells available for recruitment into existing circuits (for reviews see Gould et al., 1999b; Gross, 2000; Kempermann et al., 2004; Shors, 2004).”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “However, the identification of the neuronal phenotype of newly generated cells using these markers is considered ambiguous as they also label other types of cells (189, 411, 453, 454).”