Monocyte chemoattractant protein 1 in obesity and insulin resistance

By P. Sartipy, D. Loskutoff. Proceedings of the National Academy of Sciences of the United States of America, 2003

1,214 citations recorded by the source corpus.

Subfields: Epidemiology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/2eb13d8aaa27ae72fddd2903e18011669d68c7e6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Oncology

In Physiology

Citations in the corpus

Impact of Obesity and Metabolic Syndrome on Immunity. (2016, background): “Persistent stress and inflammation within adipose tissue can lead to adipocyte apoptosis and the release of chemotactic mediators, resulting in inflammatory leukocyte infiltration (78).”
Increased oxidative stress in obesity and its impact on metabolic syndrome. (2004, background): “Recent studies have shown that the dysregulated production of " offensive " adipocytokines, such as PAI-1 (10), TNF-α (11, 12), IL-6 (45), MCP-1 (46), and angiotensinogen (47), and of " defensive " adipocytokines, such as adiponectin (18–20) and leptin (15–17), is critically involved in the pathogen”
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “Ob/ob mice, a commonly used mouse strain that spontaneously develops obesity due to leptin deficiency-induced hyperphasia, as well as diet-induced obese mice, display elevated levels of plasma Mcp-1 and Ccl2 adipose tissue expression (213, 274, 275).”
Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss (2010, background): “10 inflammation pathologies like obesity and diabetes (35-37).”
Adipokines in inflammation and metabolic disease (2011, background): “In addition, genetically obese ( ob/ob ) mice and diet-induced obese mice have high levels of CCL2 expression in their white adipose tissue, and this observation has been extended to human”
Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. (2005, background): “The white adipose tissue (WAT) of obese subjects is characterized by increased production and secretion of a wide panel of inflammatory molecules, including tumor necrosis factor- (2), interleukin (IL) 6 (3), transforming growth factor- (4), monocyte chemotactic protein (MCP)-1 (5), and plasminogen ”
Obesity is associated with macrophage accumulation in adipose tissue. (2003, background): “Among these molecules, TNF-α, IL-6, PAI-1, NO, factor VII, and MCP-1 have been implicated in the development of adverse pathophysiological phenotypes associated with obesity (25, 69).”