Serotonin Transporter Genetic Variation and the Response of the Human Amygdala

By Ahmad R. Hariri, Venkata S. Mattay, Alessandro Tessitore, Bhaskar S. Kolachana, Francesco Fera, D. Goldman, Michael Egan, Daniel R. Weinberger. Science, 2002

2,387 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2d7fe243b643a7f8ed610f27e652c3fd1bd06ad6

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function (2010, background): “This paradigm has been shown to elicit robust limbic activations, particularly in the amygdala, and is known to be sensitive to genotype effects on the activation and functional interaction of limbic areas (33, 41).”
Culture–gene coevolution of individualism–collectivism and the serotonin transporter gene (2009, background): “…behaviour, such as the amygdala, varies as a function of 5-HTT. Specifically, individuals carrying the S allele show greater amygdala response (Hariri et al. 2002; Munafò et al. 2008), which is likely due to increased amygdala resting activation (Canli et al. 2005) and decreased functional…”
NEURAL CORRELATES OF EMOTIONAL MEMORIES: A REVIEW OF EVIDENCE FROM BRAIN IMAGING STUDIES (2012, background): “…(Gerritsen et al., 2011), thus suggesting that altered functioning of the AMY is not only disorder specific, but can also be observed in individuals characterized by traits linked to negative affect and hence more prone to develop affective disorders (Hariri et al., 2002; Morey et al., 2011).”
What is reinforcement sensitivity? Neuroscience paradigms for approach‐avoidance process theories of personality (2008, methodology): “For instance, using Functional Magnetic Resonance Imaging (fMRI), Hariri et al. (2002) observed substantially greater activity of the amygdala for short allele during perceptual processing of fearful and angry facial expressions.”
Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide (2003, background): “, desensitization) that are recruited to normalize expression; however, the recent demonstration that people with this 5-HT transporter polymorphism show enhanced amygdala metabolism in response to aversive stimuli (Hariri et al., 2002) highlights the significant neurological consequences that can r”
Discovering Endophenotypes for Major Depression (2004, background): “For example, significant differences have been reported between s/s and l/l genotypes of the 5-HTT promoter gene regarding the amygdala response to fearful faces measured by functional MRI in the absence of behavioral differences (Hariri et al, 2002).”
Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. (2008, background): “When the first published study (22) was removed from the analysis (k = 13), there was evidence of a significant association between 5-HTTLPR genotype and amygdala activation (Z = 5.”
Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits (2010, positive): “The S allele has been associated with altered functional coupling (as indexed by correlated fMRI signal strength) between the amygdala and regions of the medial prefrontal cortex (40, 57).”
Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. (2007, methodology): “In fact, there is already evidence amassing that the amygdala response to emotional face processing is moderated by genetic factors such as functional variation in the serotonin transporter, (46, 48, 65, 73, 74) raising the possibility that this particular endophenotype may well lend itself to furth”
Visual Attention and Brain Processes That Underlie Expert Performance: Implications for Sport and Military Psychology (2008, background): “In this regard, carriers of the short allele of the promoter region of the serotonin transporter gene (5-HTT; about 50% of population) show heightened activation of the amygdalae to emotion-eliciting stimuli, whereas those carrying the long allele show attenuation of activation and report less fear ”
The evolutionary genetics of personality (2007, background): “In the exemplary case of neuroticism, amygdala reactivity (Hariri et al., 2002, 2005) provides an especially good example of a mediating endophenotype, though there are likely several others.”