CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth.
By T. Ishimoto, O. Nagano, Toshifumi Yae, M. Tamada, T. Motohara, H. Oshima, M. Oshima, Tatsuya Ikeda, Rika Asaba, H. Yagi and 11 more. Cancer Cell, 2011
1,134 citations recorded by the source corpus.
Subfields: Biochemistry, Cancer Research, Oncology
View Paper: https://www.semanticscholar.org/paper/5fb4329f67770c748c0b776e70364a09e14dd4f9
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In Biochemistry
- Donna D. Zhang
- Masayuki Yamamoto
- Pranavi Koppula
- B. Gan
- G. J. Yoshida
- Zhuang Li
- Miriama Šimunková
- M. Valko
In Cancer Research
In Oncology
Citations in the corpus
- Metabolic reprogramming: the emerging concept and associated therapeutic strategies (2015, background): “CSCs possess several biological features of “stemness”, a combination of phenotypes including plasticity in the transition between quiescent (G0 phase) and proliferative states [6] and resistance to redox stress and chemotherapeutic agents [7, 8].”
- Targeting Free Radicals in Oxidative Stress-Related Human Diseases. (2017, background): “xCT is a glutamate/cystine transporter and its expression at the cell surface is essential for the uptake of cystine that is required for intracellular GSH synthesis [37].”
- NRF2 and the Hallmarks of Cancer. (2018, background): “CSCs are refractory to conventional anticancer treatments, mostly due to their low proliferative index, high antioxidant capacity, and high expression of drug efflux transporters and anti-apoptotic proteins (Shibue and Weinberg, 2017, Ishimoto et al., 2011, Jia et al., 2015, Diehn et al., 2009).”
- From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy (2016, neutral): “BPTES inhibition of hGA(124-551), a truncated form of human kidneytype glutaminase.”
- The emerging role of the Nrf2–Keap1 signaling pathway in cancer (2013, background): “Recent studies have revealed that glutathione is critical for cell proliferation (Reddy et al. 2007a,b; Ishimoto et al. 2011).”