Metastatic Stem Cells: Sources, Niches, and Vital Pathways

By Thordur Oskarsson, E. Batlle, J. Massagué. Cell Stem Cell, 2014

691 citations recorded by the source corpus.

Metastasis is powered by disseminated cancer cells that recreate a full-fledged tumor in unwelcoming tissues, away from the primary site. How cancer cells moving from a tumor into the circulation manage to infiltrate distant organs and initiate metastatic growth is of interest to cancer biologists and clinical oncologists alike. Recent findings have started to define the sources, phenotypic properties, hosting niches, and signaling pathways that support the survival, self-renewal, dormancy and reactivation of cancer cells that initiate metastasis–metastatic stem cells. By dissecting the biology of this process, vulnerabilities are being exposed that could be exploited to prevent metastasis.

Subfields: Biotechnology, Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/5908cb400c0b503104f630c52c75ecd06342eb49

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. R. Weinberg
2. D. Pattabiraman
3. Arthur W. Lambert
4. Zena Werb
5. Niwen Kong
6. V. Plaks
7. J. Joyce
8. E. Song

In Cancer Research

1. R. Weinberg
2. D. Pattabiraman
3. Arthur W. Lambert
4. J. Joyce
5. Zena Werb
6. V. Plaks
7. Niwen Kong
8. D. Quail

In Oncology

1. R. Weinberg
2. Zena Werb
3. D. Pattabiraman
4. Arthur W. Lambert
5. V. Plaks
6. J. Joyce
7. Niwen Kong
8. D. Quail

Citations in the corpus

• The microenvironmental landscape of brain tumors (2017, background): “, 2012), which interestingly are also critical niche factors for promoting cancer cell survival (Oskarsson et al., 2014).”
• Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment (2018, background): “The cells within CSC microenvironment are capable of stimulating signaling pathways [58], such as Notch [102, 107, 108] and Wnt [109–111] which may facilitate CSCs to metastasize, evade anoikis, and alter divisional dynamics, achieving repopulation by symmetric division [109, 112–114].”
• EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “Thus, it appears that the metastatic potential of a carcinoma is closely related to its ability to dispatch populations of CSCs that can re-initiate tumor growth following arrival at distant sites (Oskarsson et al., 2014).”
• The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, positive): “The TME Supports Cancer Cell Dissemination Beyond the passive role of circulation patterns, cancer cell dissemination is actively influenced by cancer cell autonomous functions such as invadopodia formation, paracrine factors as VEGF and Epidermal growth factor (EGF) family members, proteases as MMP”
• CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. (2018, positive): “It has been shown that cancer stem cells (CSCs) are a key population of tumor cells that are highly tumorigenic and chemoresistant in many cancer types (Korkaya et al., 2012; Oskarsson et al., 2014; Yu et al., 2007).”