Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine

By Mark J. Thomas, C. Beurrier, A. Bonci, R. Malenka. Nature Neuroscience, 2001

635 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/2c1c6c1b5b0dff0a02ebd492794ea2e6810c0cb1

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In Cognitive Neuroscience

Citations in the corpus

A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes. (2005, background): “…and elicits a long-lasting depression of synaptic strength at synapses made by prefrontal cortical afferents onto medium spiny neurons in the shell subdivision of the nucleus accumbens, a change that is required for the maintenance of behavioral sensitization and addiction (Thomas et al. 2001).”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, methodology): “In one study chronic (5 days) cocaine administration followed by 10–14 days of withdrawal caused a decrease in the AMPA/NMDA ratio (Thomas et al. 2001).”
The Endocannabinoid System as an Emerging Target of Pharmacotherapy (2006, background): “This mechanism has also been implicated in LTD (Gerdeman et al., 2002; Robbe et al., 2002), a form of synaptic plasticity that can be initiated by drugs of abuse (Thomas et al., 2001), and may be involved in certain features of compulsive drug use (Gerdeman et al., 2003).”
Adolescent cortical development: a critical period of vulnerability for addiction. (2007, background): “, 2001), VTA (Thomas et al., 2001) and hippocampus (Adriani et al.”
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling (2011, methodology): “Noncontingent administration of cocaine for 5 days caused a decrease in the AMPAR/NMDAR ratio at synapses on NAc MSNs when measured 24 hr later or after a single challenge dose of cocaine following a 10–14 day withdrawal period (Kourrich et al., 2007; Thomas et al., 2001).”
Computational models of reinforcement learning: the role of dopamine as a reward signal (2010, background): “…of the VTA, including the NAc (Kombian and Malenka 1994; Li and Kauer 2004; Pennartz et al. 1993; Robbe et al. 2002; Taverna and Pennartz 2003; Thomas et al. 2001), PFC (Otani et al. 2003) and amygdala (Bauer and LeDoux 2004; Bauer et al. 2002; Fourcaudot et al. 2009; Huang and Kandel 1998,…”
Psychomotor Stimulant Addiction: A Neural Systems Perspective (2002, background): “Psychostimulants therefore may influence LTP and LTD in corticostriatal and other pathways by acting at a systems level to alter neuronal activity in excitatory pathways.”
The reinstatement model of drug relapse: history, methodology and major findings (2003, background): “the NAc (Thomas et al. 2001).”
Structural plasticity associated with exposure to drugs of abuse. (2004, neutral): “…implicated in persistent forms of drug experience-dependent behavioral plasticity, such as behavioral sensitization (Kalivas, 1995; Wolf, 1998), as well as in drug experiencedependent changes in synaptic signaling measured electrophysiologically (Thomas et al., 2001; Li and Kauer, 2004).”
Prefrontal Glutamate Release into the Core of the Nucleus Accumbens Mediates Cocaine-Induced Reinstatement of Drug-Seeking Behavior (2003, background): “Furthermore, there is a reduction in electrophysiological sensitivity of AMPA glutamate receptors to electrical stimulation of the prefrontal cortex (Thomas et al., 2001), and an enhanced inhibitory effect of dopamine on excitatory AMPA currents (White et al., 1995; Beurrier and Malenka, 2002).”