Prefrontal Glutamate Release into the Core of the Nucleus Accumbens Mediates Cocaine-Induced Reinstatement of Drug-Seeking Behavior

By K. McFarland, Christopher C. Lapish, Peter W. Kalivas. Journal of Neuroscience, 2003

914 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4409827c3913e132f9c136ed0034845df47f039b

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Citations in the corpus

Drug Addiction as a Pathology of Staged Neuroplasticity (2008, background): “…REVIEWS REVIEW learning to seek biological rewards (McFarland et al, 2003).”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “…diverse structures as the NAc, PFC, amygdala, and dorsal striatum may bring together information about the motivational state of the organism with specific sensory information (whether interoceptive or in the environment) and stored motor responses (Figure 5) (McFarland et al. 2003, Kalivas 2004).”
Neurocircuitry of Addiction (2009, background): “…rats, microdialysis and microinjection studies have shown that following chronic cocaine, decreased basal release of glutamate occurs but sensitized synaptic glutamate release during reinstatement of extinguished drug-seeking in rats (Kalivas and O’Brien, 2008; McFarland et al, 2003).”
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion (2005, background): “as well as dopamine and glutamate transmission in the basolateral amygdala and nucleus accumbens cor”
Extinction circuits for fear and addiction overlap in prefrontal cortex. (2009, background): “Glutamate released from PLmPFC within the core triggers relapse for both cocaine and heroin (McFarland et al. 2003, 2004; LaLumiere and Kalivas 2008; Fig.”
The neural basis of addiction: a pathology of motivation and choice. (2005, background): “Dopamine release in the prefrontal cortex is antecedent to activation of the projection from the prefrontal cortex to the accumbens core since preventing cortical dopamine release prevents glutamate release in the nucleus accumbens by a stress or drug prime (29, 58).”
Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics (2007, background): “While drug and drug-associated stimuli can elicit dopamine release in the ventral striatum and thus reinforce drug intake during the acquisition of dependent behavior, chronic drug intake is associated with neuroadaptation of glutamatergic neurotransmission in the ventral striatum and limbic cortex ”
Addiction: a disease of learning and memory. (2005, background): “org cumbens, prefrontal cortex, amygdala, and dorsal striatum (68, 69) that brings together specific sensory information or specific action sequences with information about the motivational state of the organism and the incentive salience of cues in the environment.”
Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior (2011, background): “…reinstatement of cocaine- and heroin-seeking behavior (Meil and See, 1997; Kruzich and See, 2001; Fuchs and See, 2002; Kantak et al., 2002; McLaughlin and See, 2003), whereas the dorsal and ventral hippocampus have been implicated in contextand cue-dependent reinstatement, respectively…”