Requirement of a critical period of transcription for induction of a late phase of LTP.

By P. Nguyen, Ted Abel, E. Kandel. 1994

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Translational regulatory mechanisms in persistent forms of synaptic plasticity. (2004, unknown): “immediate effect (Nguyen et al., 1994; Frey et al., 1996; Frey and Morris, 1997; Scharf et ton et al., 2001). al., 2002).”
Translational control by MAPK signaling in long-term synaptic plasticity and memory. (2004, background): “an early, progrestant mice to cued fear conditioning, a hippocampussive decay of L-LTP (Frey et al., 1996, 1988; Frey and independent version of the task in which a tone consti- Morris, 1997; Nguyen et al., 1994).”
Cerebellar long-term depression: characterization, signal transduction, and functional roles. (2001, background): “The translational inhibitors depress the late phase of LTP in hippocampal neurons (152, 153, 411).”
Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation (2007, background): “As in CREB knock-outs, slices from cbpKIX/KIX mutant mice still exhibit the transient potentiation characteristic of E-LTP (compare vehicle-treated slices in Fig.”
Dendritic protein synthesis, synaptic plasticity, and memory. (2006, result): “Given that transcriptional activation at the cell soma is required for late-phase LTP in normal hippocampal slices (Nguyen et al., 1994), initial ideas regarding the sites of translational control naturally focused on the cell soma, and early studies provided some support for this idea (Frey et al.”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “…can be mediated by local events at the synapse, such as AMPA receptor phosphorylation and insertion into the postsynaptic membrane, longer-term changes require a broader coordination of cellular mechanismsFin particular, induction of genes and production of new protein (Nguyen et al, 1994).”
The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses (2001, background): “So Uwe Frey, Yan-You Huang, Peter Nguyen, and I examined whether LTP changed with repeated stimulation [71, 72, 73] and found that in each of the three major hippocampal pathways LTP has phases, much like facilitation in Aplysia.”
The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response Element-Binding Protein to Control Long-Term Potentiation-Dependent Gene Expression in the Dentate Gyrus In Vivo (2000, background): “Because the maintenance of these forms of plasticity requires gene transcription ( Nguyen et al., 1994; Bartsch et al., 1995), we have addressed the issue of whether and how activation of MAPK/ERK can mediate gene induction in LTP by measuring the expression of the IEG zif268, known to be strongly ”
How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory (2019, background): “1998; Stanton and Sarvey 1984) and requires transcription beyond a time scale of a few hrs (Nguyen et al. 1994).”
Learning rules and persistence of dendritic spines (2010, background): “(Davis & Squire, 1984; Qian et al., 1993; Nguyen et al., 1994; Bailey et al., 1996; Kelleher et al., 2004; Sutton & Schuman, 2006; Fischer et al., 2007)? This question is particularly interesting because both enlargement (or LTP; Tanaka et al.”