The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses

By E. Kandel. Science, 2001

3,808 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/02a9b5080741eab5f6b0f1b1d357cc42fd2e8ad7

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

An essential switch in subunit composition of a chromatin remodeling complex during neural development. (2007, background): “Epigenetic regulatory mechanisms, such as histonemodification, polyADP-ribosylation, DNA methylation, regulatory noncoding RNAs, and even retrotransposition have been linked with changes in neural plasticity and long-term memory (reviewed in Hsieh and Gage [2005], Kandel [2001] ).”
Report Nociceptive Sensitization Reduces Predation Risk (2014, neutral): “Although neural mechanisms of nociceptive sensitization have received extensive study in the contexts of pain [18, 19] and aversive learning [20, 21], and its adaptive value for recuperative behavior, contextual learning, and defense against potential attackers has been conjectured [1, 22–24], until”
Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease (2010, background): “Associative learning activates biochemical signaling pathways that trigger the synthesis of new proteins necessary for the consolidation of hippocampus-dependent memories (Kandel, 2001; McGaugh, 2000).”
Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory (2005, background): “Indeed, some believe that prolonged consolidation effects a transfer of the same memory from one location to another (see Kandel, 2001, p. 1038) or strengthens the neocortical traces which initially were bound together by the hippocampus, a process that may be supplemented by repetition of the…”
NF-κB/Rel Regulates Inhibitory and Excitatory Neuronal Function and Synaptic Plasticity (2006, background): “Stimulus-coupled changes in synaptic plasticity are required for the storage, retrieval, and removal of acquired information collectively referred to as memory formation (28, 32 , 39).”
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity (2017, background): “Molecular processes responsible for hippocampal synaptic potentiation can be categorized, depending on the time course, into short and long term (Abraham 2003; Kandel 2001; Leal et al. 2015; Sweatt 1999), and BDNF can modify both of them.”
Evolutionary Biology of Animal Cognition (2004, background): “In contrast, close to 100% of aboriginal Africans and North Americans identify PTC as bitter (Kalmus 1971, Prutkin et al. 2000).”
The molecular and systems biology of memory. (2014, positive): “Abrams analyzed the presynaptic component and found that an influx of calcium ions into the sensory neuron, which occurs during paired firing, enhances the activity of Ca-sensitive adenylyl cyclase, the enzyme that synthesizes cAMP (Kandel, 2001; Abrams et al., 1991).”
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. (2004, background): “Intensive studies of the mechanisms underlying hippocampal long-term potentiation (LTP) and memory formation have delineated central roles for NMDA receptors, calcium/calmodulin-dependent kinase II (CaMKII), and cAMP response element (CRE)dependent gene expression, which is mediated by the transcrip”