Dendritic protein synthesis, synaptic plasticity, and memory.

By M. A. Sutton, E. Schuman. Cell, 2006

907 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Computational Theory and Mathematics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b4cea8d90f74bfd8c66b9be0d31822313a0c56e2

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In Cellular and Molecular Neuroscience

In Computational Theory and Mathematics

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Citations in the corpus

A census of human RNA-binding proteins (2014, background): “splicing, RNA transport, storage, and translation are critical for neuroplasticity (Jung et al., 2014; Kandel et al., 2014; Sutton and Schuman, 2006).”
Translational control of long-lasting synaptic plasticity and memory. (2009, neutral): “…synthesis machinery, including ribosomes, translation factors, and mRNAs, are present in dendrites and dendritic spines (Steward and Schuman, 2001; Sutton and Schuman, 2006), it was also posited that long-lasting plasticity could be engendered through the activation of local protein synthesis,…”
Neuronal homeostasis: time for a change? (2011, background): “In addition, mRNAs and polyribosomes are found in neuronal processes and have been demonstrated to mediate local, activity-dependent protein synthesis (Sutton & Schuman, 2006) and regulate dendritic ion channel expression (Raab-Graham et al. 2006).”
Dendritic excitability and synaptic plasticity. (2008, neutral): “Although processes such as these do not depend on diffusion, but on active transport (525, 577, 697, 751, 752, 863), the physical compartmentalization provided by spines may endow neurons with a privileged environment that is important for controlling a subset of biochemical processes specific to sy”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, background): “In neurons, some mRNAs are transported along the dendrites as repressed mRNPs to become translated at dendritic spines upon synaptic activatio”
TrkB signalling pathways in LTP and learning (2009, background): “L-LTP induction is widely believed to depend on both local dendritic protein synthesi”
Dendritic mRNA: transport, translation and function (2007, background): “24, 9760–9769 (2004). consolidation involve the simultaneous rapid synthesis and degradation of proteins.”
Learning rules and persistence of dendritic spines (2010, background): “…spine structure and function, why does the formation of long-term memory depend on protein synthesis, gene transcription and epigenetic factors (Davis & Squire, 1984; Qian et al., 1993; Nguyen et al., 1994; Bailey et al., 1996; Kelleher et al., 2004; Sutton & Schuman, 2006; Fischer et al., 2007)?”
Nanoconnectomic upper bound on the variability of synaptic plasticity (2015, background): “…Capacity for local ribosomal protein synthesis in some spines while others depend on transport of proteins from the dendrites (Ostroff et al., 2002; Sutton and Schuman, 2006; Bourne et al., 2007; Bourne and Harris, 2011); 8) Homeostatic mechanisms for synaptic scaling may vary (Turrigiano, 2008;…”
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “This so-called ‘late phase of LTP’ (defined as the potentiation present more than 1–2 h after LTP induction) is commonly assumed to depend upon local dendritic protein synthesis, which supplies needed components to the synapse (Sutton and Schuman, 2006), as well as transcription in the nucleus (Zhou”
Negative Regulation of Active Zone Assembly by a Newly Identified SR Protein Kinase (2009, background): “There is also increasing evidence in support of local translation in dendrites and for the presence of Golgi outposts that could support local protein maturation [36,37].”