Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity.

By A. Itano, S. McSorley, R. Reinhardt, B. Ehst, E. Ingulli, Alexander Y. Rudensky, M. Jenkins. Immunity, 2003

809 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2ba78e06ed20f03e9af4edde150300c4f3be5d7b

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In Immunology

Citations in the corpus

Monocyte-mediated defense against microbial pathogens. (2008, background): “Under infectious or inflammatory conditions, skin-draining lymph nodes contain a number of non-LC DC populations that have been implicated in antigen presentation and T cell priming (57).”
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice (2006, background): “After entering the lymph node through high endothelial venules, T cells traverse through an area bordering the paracortical T cell zone and B cell follicles, where tissue-emigrant DCs congregat”
Translating innate immunity into immunological memory: implications for vaccine development. (2006, positive): “Recent work, however, suggests the concerted action of resident DC subsets and DCs that migrate from the periphery in serial waves (Itano et al., 2003), each of which are specialized to perform distinct functions such as ferrying the antigen to the site, crosspresentation to CD8 T cells, IL-12 secre”
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts (2006, background): “Skin-derived DCs present alloantigen and migrate through lymphatics to local draining lymph nodes, where they prime antigen-specific T cell”
Minimal differentiation of classical monocytes as they survey steady state tissues and transport antigen to lymph nodes (2013, background): “Soluble antigen is largely sequestered in LN conduits, and it appears that sampling of antigen from conduits alone is insufficient to drive a productive immune response (Itano et al., 2003).”
Homing and cellular traffic in lymph nodes (2003, background): “Two mechanisms of antigen delivery can be distinguishe”
Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. (2005, background): “with recent data obtained on bulk, tissue-derived DCs (Itano et al., 2003; Wilson et al., 2003), incoming LCs found in draining CLNs after TRITC painting did not exhibit a more mature surface phenotype than that of LCs reaching CLNs under noninflammatory conditions.”