Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts

By J. Ochando, Chiho Homma, Yu Yang, A. Hidalgo, Alexandre Garin, F. Tacke, V. Angeli, Yansui Li, P. Boros, Yaozhong Ding and 5 more. Nature Immunology, 2006

701 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/eaefe0c3766747d3e2424726d4b7837df6562889

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In Immunology

1. V. Kuchroo
2. Yong‐jun Liu
3. M. Gilliet
4. M. Oukka
5. A. Thomson
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7. Peter Libby
8. R. Flavell

Citations in the corpus

• Plasmacytoid Dendritic Cells: Recent Progress and Open Questions (2011, background): “In vivo, pDCs were proposed to promote Treg differentiation in the human thymus (107) and to induce Treg-mediated tolerance in tumor-bearing mice (108), during tolerization to cardiac allografts (109), in experimental autoimmune encephalomyelitis (EAE) (110), and in graftversus-host disease (111).”
• Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand (2007, background): “pDCs were shown to suppress infl ammatory responses to inhaled allergens (39), microbial infections (40), and tumors (41), to promote allogeneic stem cell engraftment (42), and to mediate tolerance to solid grafts by inducing T regulatory cells (43).”
• A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells (2007, background): “In addition to generating IL-10-producing T cells, plasmacytoid DCs can also induce T cell tolerance by promoting the generation and population expansion of Foxp3 + T reg cell”
• Tolerogenic dendritic cells and the quest for transplant tolerance (2007, background): “Recipient pDCs can acquire and process alloantigen in heterotopic (intra-abdominal) cardiac allografts in mice and then, as partially matured APCs, preferentially migrate through the blood to lymph nodes (rather than the spleen), where they induce the generation of donor-specific T Reg cell”
• Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “During cardiac transplant, Treg expansion required the migration of alloantigen-presenting pDCs into the draining LNs, which then produced CCL17, resulting in a CCR4-mediated colocalization of Foxp3+ Tregs with these APCs and their activation (225).”
• The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models (2008, result): “By contrast, in the same model, adoptive transfer of tolerized alloantigen-presenting pDCs induced regulatory T-cell development and prolonged graft surviva”