The Hippo Pathway: Biology and Pathophysiology.
By Shenghong Ma, Z. Meng, Rui Chen, K. Guan. Annual Review of Biochemistry, 2019
1,139 citations recorded by the source corpus.
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size control, and regeneration. The core of the Hippo pathway in mammals consists of a kinase cascade, MST1/2 and LATS1/2, as well as downstream effectors, transcriptional coactivators YAP and TAZ. These core components of the Hippo pathway control transcriptional programs involved in cell proliferation, survival, mobility, stemness, and differentiation. The Hippo pathway is tightly regulated by both intrinsic and extrinsic signals, such as mechanical force, cell-cell contact, polarity, energy status, stress, and many diffusible hormonal factors, the majority of which act through G protein-coupled receptors. Here, we review the current understanding of molecular mechanisms by which signals regulate the Hippo pathway with an emphasis on mechanotransduction and the effects of this pathway on basic biology and human diseases.
Subfields: Cell Biology
View Paper: https://www.semanticscholar.org/paper/823581eb3ce074bd0f9ed227ee4b2f6f1adb9670
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
Citations in the corpus
- The Hippo signalling pathway and its implications in human health and diseases (2022, background): “20,249 In contrast, Hippo pathway inactivation can play suppressive roles against the migration and invasion of cells.”
- Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments (2023, background): “Abnormal activation of Hippo core factors Yes1 associated transcriptional regulator (YAP) and WW domain containing transcription regulator (TAZ, or WWTR1) sustain cell proliferation and is prevalently detected in various cancers, implying the success adaption of cancer to crowed environment [137, 13”