The Hedgehog Response Network: Sensors, Switches, and Routers

By L. Lum, P. Beachy. Science, 2004

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Hedgehog: functions and mechanisms. (2008, background): “In addition to many multifunctional proteins, the Hh pathway consists of 11 known specific components: Hh, Skinny hedgehog (Ski), Dispatched, iHog/boi, Ptc, Smo, Cos2, Fu, Su(Fu), and Ci (Burke et al. 1999; Chamoun et al. 2001; Lum and Beachy 2004).”
Multisite Protein Kinase A and Glycogen Synthase Kinase 3β Phosphorylation Leads to Gli3 Ubiquitination by SCFβTrCP (2006, background): “Deletion of the Nor C-terminal domain significantly diminished the levels of truncated Gli3 expressed from the corresponding N[461-1595] and C[1-1100] fragments (Fig.”
Basal cell carcinomas: attack of the hedgehog (2008, background): “Although a complete description of the intricacies of HH signalling is outside the focus of this Review (see Ref”
G-protein-coupled receptors and cancer (2007, background): “Hedgehog and Wnt: roles for G proteins Smoothened ( SMO ) is a seven-transmembrane receptor that is negatively regulated by the twelve-transmembrane receptor patched (PTCH”
Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma (2007, background): “Smo activates the canonical Hh pathway through Glidependent transcription of multiple targets, including N-myc, cyclin D, Ptch, Gli1, and Gli2 [13, 14 ].”
Communicating with Hedgehogs (2005, background): “(see Box 1 ); its unique mode of signal transductio”