G-protein-coupled receptors and cancer

By R. Dorsam, J. Gutkind. Nature Reviews. Cancer, 2007

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SCFA: mechanisms and functional importance in the gut (2020, background): “GPR43 engagement stimulates the phospholipase-Cβ, which releases intracellular Ca and activates protein kinase C in addition to cAMP accumulation inhibition and protein kinase A and ERK activation((59)).”
GAGE: generally applicable gene set enrichment for pathway analysis (2009, neutral): “Indeed, Gprotein-coupled receptors, the largest family of cell-surface molecules involved in signal transmission, have emerged as crucial players in the growth and metastasis of multiple human cancers [24,25].”
Regulation of the Hippo-YAP pathway by G-protein coupled receptor signaling (2012, background): “GPCR signaling plays important roles in cancer development as both familial and somatic activating mutations of GPCRs have been linked to human cancer (Dorsam and Gutkind, 2007).”
The Hippo pathway: regulators and regulations. (2013, background): “GPCRs are crucial players in cancer development, and dysregulated GPCR signaling has been identified in many types of human cancers (Dorsam and Gutkind 2007).”