The Controversial Role of Human Gut Lachnospiraceae
By M. Vacca, Giuseppe G. A. Celano, Francesco Maria Calabrese, P. Portincasa, M. Gobbetti, M. De Angelis. Microorganisms, 2020
1,403 citations recorded by the source corpus.
The complex polymicrobial composition of human gut microbiota plays a key role in health and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal lumen from birth and increasing, in terms of species richness and their relative abundances during the host’s life. Although, members of Lachnospiraceae are among the main producers of short-chain fatty acids, different taxa of Lachnospiraceae are also associated with different intra- and extraintestinal diseases. Their impact on the host physiology is often inconsistent across different studies. Here, we discuss changes in Lachnospiraceae abundances according to health and disease. With the aim of harnessing Lachnospiraceae to promote human health, we also analyze how nutrients from the host diet can influence their growth and how their metabolites can, in turn, influence host physiology.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/7f581e4061d266476a3fb45fe6a2812b4f0690c0
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In Molecular Biology
Citations in the corpus
- Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis (2022, background): “, 2010 [114] Hyperinsulinaemic individuals 28 24–27 Parallel 1 year High-wheat fiber cereal consisting of 24 g fiber/day compared with low-fiber cereal ↑ Acetate and butyrate concentrations ↑ Plasma GLP-1”
- Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota (2023, background): “As previously mentioned, the main species involved in the production of butyrate are found within the Lachnospiraceae and Ruminococcaceae families [95,96].”