The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.

By Michael Egan, M. Kojima, J. Callicott, Terry E. Goldberg, Bhaskar S. Kolachana, A. Bertolino, E. Zaitsev, B. Gold, D. Goldman, M. Dean and 2 more. Cell, 2003

3,866 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/29748e8341cdd63161a93508addc0390a3ceb1df

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

The yin and yang of neurotrophin action (2005, background): “An important advance came from a study showing that a single-nucleotide polymorphism in the pro-domain of the human BDNF gene affects the trafficking and secretion of BDN”
Potential therapeutic uses of BDNF in neurological and psychiatric disorders (2011, background): “In this manner, BDNF influences learning and memor”
The Adolescent Brain and the Emergence and Peak of Psychopathology (2015, background): “The presence of this substitution leads to a reduction in the activity-dependent release of BDNF (Egan et al., 2003).”
Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning (2010, neutral): “We trained 34 subjects (Val/ Val: n = 17, Met carriers: n = 17, Val/Met [16], Met/Met [1]) on the same pinch-force task while applying anodal tDCS to M1.”
Neurotrophin-regulated signalling pathways (2006, background): “A polymorphism in the bdnf gene that impairs the transport of BDNF protein has been associated with impaired hippocampal function and episodic memory (Egan et al. 2003).”
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. (2007, background): “…October 19, 2007 ª2007 Elsevier Inc. 401 Met allele suggest that while this variant may confer unfavorable effects on hippocampal function (Chen et al., 2006; Egan et al., 2003), its effects on mesolimbic BDNF signaling may represent a compensatory biological advantage under adverse conditions.”
Molecular Genetics of Attention Deficit Hyperactivity Disorder (2010, background): “A polymorphism producing an amino acid substitution (valine to methionine) at codon 66 of the BDNF may impact intracellular trafficking and activity-dependent secretion of BDNF.157 Kent and colleagues158 found over transmission of the Val66 allele and that this was accounted for by paternal (P 5 .00”
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity (2017, background): “Apart from the two above-mentioned isoforms, the functioning of BDNF is significantly affected by the single- nucleotide polymorphism of methionine (Met) to valine (Val) substitution at position 66 within the BDNF gene in the pro-domain encoding region (Egan et al. 2003).”
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin (2005, background): “Indeed, even modest impairment in BDNF secretion, which occurs secondary to a fairly prevalent polymorphism in humans, has been correlated with neuropsychiatric conditions and abnormalities in episodic memory (Egan et al., 2003; Jiang et al., 2005).”
Polygenic Influence on Educational Attainment: New evidence from The National Longitudinal Study of Adolescent to Adult Health (2015, background): “For example, in the case of the SNP rs6265 in the BDNF gene, the substitution of an A allele for the more common G allele results in an amino acid substitution from valine to methionine, in turn resulting in altered production of the BDNF peptide (Egan et al., 2003).”
Candidate mechanisms for chemotherapy-induced cognitive changes (2007, background): “The methionine allele has been associated with poorer performance on measures of memory and executive function and lower hippocampal volum”
Psychobiology and molecular genetics of resilience (2009, neutral): “It is also associated with reduced hippocampal volum”