Candidate mechanisms for chemotherapy-induced cognitive changes

By T. Ahles, Andrew J. Saykin. Nature Reviews. Cancer, 2007

895 citations recorded by the source corpus.

Subfields: Genetics, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/aa37f4f2ed580a8f3c02667895415606854a0c9a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Shelli R. Kesler
2. J. Joyce
3. D. Quail
4. T. Ahles

In Pulmonary and Respiratory Medicine

1. Shelli R. Kesler
2. T. Ahles

Citations in the corpus

• GAT: A Graph-Theoretical Analysis Toolbox for Analyzing Between-Group Differences in Large-Scale Structural and Functional Brain Networks (2012, background): “First, while the mechanism by which cancer and its treatments affect cognitive function are largely unknown, possible candidates include neurotoxic effects of chemotherapy, oxidative damage and cytokine dysregulation [32,33].”
• PREVALENCE, MECHANISMS, AND MANAGEMENT OF CANCER-RELATED COGNITIVE IMPAIRMENT (2014, background): “…dysfunction, loss of appetite, withdrawal and other psychological symptoms: all symptoms experienced by cancer patients) (Dantzer & Kelley, 2007), and this has led several investigators to propose infl ammation as central to CRCI aetiology (Ahles & Saykin, 2007; Cleeland et al., 2003; Raffa, 2011).”
• Cancer- and cancer treatment-associated cognitive change: an update on the state of the science. (2012, background): “No explanation for this phenomenon currently exists; however, two nonmutually exclusive hypotheses have been proposed: one, the biology of cancer (eg, inflammatory response triggering neurotoxic cytokines) may contribute to lower than expected cognitive performance; and/or two, common risk factors f”
• The microenvironmental landscape of brain tumors (2017, background): “Adverse effects from these treatment regimens range in severity between individuals, and can include loss of BBB integrity, cytokine deregulation, and, ultimately, changes in neuronal integrity and cognitive function, particularly in children (Ahles and Saykin, 2007).”