Sex differences in autoimmune disease

By C. Whitacre. Nature Immunology, 2001

1,382 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2900348f8611603c7a79d039d0dd632f7822e66f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Rheumatology

Citations in the corpus

Sex hormones and the immune response in humans. (2005, background): “Also disease expression is affected by the reproductive status; patients with immune-based diseases, such as multiple sclerosis, asthma or systemic lupus erythematosis (SLE), may have exacerbations during specific periods of the menstrual cycle or pregnancy (Skobeloff et al., 1996; Case and Reid, 19”
Population Incidence of Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis (2011, positive): “The male predominance in GBS differs from that of most other autoimmune diseases such as multiple sclerosis and systemic lupus erythematosus, which frequently demonstrate higher rates in females [37, 38].”
Sex Bias in Neuroscience and Biomedical Research (2010, neutral): “N IH -PA Author M anuscript N IH -PA Author M anuscript 2009), in cardiovascular disease (Barrett-Connor, 1997, Berger et al., 2009) and in autoimmune dysfunction (Fish, 2008; Lockshin, 2006; Whitacre, 2001).”
Gender bias in autoimmunity is influenced by microbiota (2013, background): “Sexual dimorphism is a characteristic feature of many major autoimmune diseases (Fish, 2008; Whitacre, 2001).”
Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation (2015, background): “Together, these findings have implications for understanding the differential risk profile for inflammatory disorders between the sexes (114).”
Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors (2007, background): “Sex Hormones Estrogens in high levels appear to shift the immune response from the proinflammatory type 1, dominant in MS, to the noninflammatory type 2.(98,99) This effect may explain the decrease in the number of MS relapses in pregnancy, when estrogen levels are high, and its rebound in the puerp”
Sex differences in autism spectrum disorders (2013, background): “For example, many disorders with autoimmune etiologies, such as multiple sclerosis and systemic lupus erythematosis, are female predominant [1], whereas some neurodevelopmental disorders, such as attention deficit hyperactivity disorder and language”
Sexual Dimorphism in Innate Immunity (2019, neutral): “reported in SLE, whose incidence is approximately nine times higher in women relative to men [66].”
Men: good health and high mortality. Sex differences in health and aging (2008, background): “Studies generally show that women have a significantly higher mean number of reported symptoms, prevalence of migraine, musculoskeletal and autoimmune diseases, whereas men have an earlier and higher incidence of cardiovascular diseases (27, 28).”
Neuroinflammation and depression: A review (2020, background): “Interestingly, inflammation may be one of causes for the higher prevalence of depression in women, as the prevalence of autoimmune diseases (Whitacre, 2001) like depression (Grigoriadis & Robinson, 2007) is twice as high in women than in men, and these findings may reflect gender differences in basa”
The X-files in immunity: sex-based differences predispose immune responses (2008, background): “By contrast, ankylosing spondylitis, Goodpasture syndrome, Reiter syndrome and vasculitis all occur predominantly in males 3, 4 .”
The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues (2009, neutral): “Although organizational and activational effects of gonadal hormones also explain some sex differences in the MS-like model (Voskuhl and Palaszynski, 2001; Voskuhl, 2009), it appears that sex chromosome complement also plays a role.”