Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation

By Michael R. Irwin, Richard Olmstead, J. Carroll. Biological Psychiatry, 2015

1,741 citations recorded by the source corpus.

Background Sleep disturbance is associated with inflammatory disease risk and all-cause mortality. Here, we assess global evidence linking sleep disturbance, sleep duration, and inflammation in adult humans. Methods A systematic search of English language publications was performed, with inclusion of primary research articles that characterized sleep disturbance and/or sleep duration or performed experimental sleep deprivation, and assessed inflammation by levels of circulating markers. Effect sizes (ES) and 95% confidence intervals (CI) were extracted and pooled using a random effect model. Results A total of 72 studies (n>50000) were analyzed with assessment of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor α (TNF). Sleep disturbance was associated with higher levels of CRP (ES 0.12; 95% CI 0.05 – 0.19) and IL-6 (ES 0.20; 95% CI 0.08 – 0.31). Shorter sleep duration, but not the extreme of short sleep, was associated with higher levels of CRP (ES 0.09; 95% CI 0.01 – 0.17) but not IL-6 (ES 0.03; 95% CI −0.09 – 0.14). The extreme of long sleep duration was associated with higher levels of CRP (ES 0.17; 95% CI 0.01 – 0.34) and IL-6 (ES 0.11; 95% CI 0.02 – 0.20). Neither sleep disturbances nor sleep duration was associated with TNF. Neither experimental sleep deprivation nor sleep restriction was associated with CRP, IL-6, or TNF. Some heterogeneity among studies was found, but no evidence of publication bias. Conclusions Sleep disturbance and long sleep duration, but not short sleep duration, are associated with increases in markers of systemic inflammation.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/bdb003f18c999bfe89d91452fb4dfe262be26c76

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In Cognitive Neuroscience

1. D. Radecki
2. Luciana Besedovsky
3. T. Lange
4. G. Tabibnia

In Experimental and Cognitive Psychology

1. D. Radecki
2. Luciana Besedovsky
3. T. Lange
4. M. Haack
5. G. Tabibnia

Citations in the corpus

• The Sleep-Immune Crosstalk in Health and Disease (2019, background): “, CRP and IL-6) than short sleep duration (259), supporting the importance of a better understanding of the inflammatory consequences of disturbed sleep.”
• RESILIENCE TRAINING THAT CAN CHANGE THE BRAIN (2018, background): “The recommended sleep duration for average healthy adults is 7 to 8 hr a night (Hirshkowitz et al., 2015; Irwin et al., 2016).”
• Self-Compassion and Bedtime Procrastination: an Emotion Regulation Perspective (2018, neutral): “If we consider the consequences of bedtime procrastination for sleep duration and daily fatigue (Kroese et al. 2014a, b), and the consequences of poor sleep for health (e.g. Irwin et al. 2016), then bedtime procrastination can be viewed as a sleep behaviour that may compromise health.”