A vertebrate fatty acid desaturase with Δ5 and Δ6 activities
By N. Hastings, M. Agaba, D. Tocher, M. Leaver, J. Dick, J. Sargent, A. Teale. Proceedings of the National Academy of Sciences of the United States of America, 2001
335 citations recorded by the source corpus.
Subfields: Aquatic Science, Biochemistry, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/280ceafd1f99e4e3a1a6af824012b02fcb1ae456
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Citations in the corpus
- Towards Fish Lipid Nutrigenomics: Current State and Prospects for Fin-Fish Aquaculture (2008, methodology): “Piscine fatty acid desaturases were first cloned from zebrafish (Danio rerio) and rainbow trout using PCR techniques (Hastings et al., 2001; Seiliez et al., 2001).”
- Evolution of the membrane-bound fatty acid desaturases (2003, background): “Recently, it has been reported that the enzyme of zebrafish is able to catalyse both 5 and 6 desaturase reactions (Hastings et al., 2001).”
- Effects of diets containing vegetable oil on expression of genes involved in highly unsaturated fatty acid biosynthesis in liver of Atlantic salmon (Salmo salar) (2004, background): “A fatty acid desaturase has been cloned from zebrafish that has been shown to have both Δ6 and Δ5 desaturase activities (Hastings et al., 2001).”
- Biosynthesis of long-chain polyunsaturated fatty acids in the African catfish Clarias gariepinus: Molecular cloning and functional characterisation of fatty acyl desaturase (fads2) and elongase (elovl2) cDNAs7 (2016, background): “Similar substrate specificities were previously 368 described in D. rerio, which represented the first ever report of dual Δ6Δ5 functionality in a 369 vertebrate Fads (Hastings et al., 2001).”
- Metabolism and Functions of Lipids and Fatty Acids in Teleost Fish (2003, background): “Very recently, a fatty acid desaturase has been cloned from zebrafish that has been shown to have both Δ6 and Δ5 desaturase activities (Hastings et al., 2001).”
- Trophic ecology of Sargassum-associated fishes in the Gulf of Mexico determined from stable isotopes and fatty acids (2006, background): “…(%)Sargassum-derived consumer= δ δ 13 1C – 3 13 13 C I C C POM Sargassum POM – – ( ) × 100 δ δ 251 Mar Ecol Prog Ser 313: 249–259, 2006 reconstructing dietary histories (Iverson et al. 1997, Raclot et al. 1998, Hastings et al. 2001, Graeve et al. 2002, Gurr et al. 2002, Turner & Rooker, 2005a,b).”
- Expression of fatty acyl desaturase and elongase genes, and evolution of DHA:EPA ratio during development of unfed larvae of Atlantic bluefin tuna (Thunnus thynnus L.) (2011, background): “With the exception of a 91 zebrafish bifunctional Δ6/Δ5 Fad (Hastings et al., 2001) and an Atlantic salmon (Salmo salar) Δ5 92 Fad (Hastings et al., 2005), all have been Δ6 Fads (Zheng et al., 2004, 2005, 2009; Tocher et al., 93 2006; Gonzales-Rovira et al., 2009).”
- Molecular Cloning and Functional Characterization of Fatty Acyl Desaturase and Elongase cDNAs Involved in the Production of Eicosapentaenoic and Docosahexaenoic Acids from α-Linolenic Acid in Atlantic Salmon (Salmo salar) (2004, methodology): “The availability of sequence data has made it possible to study the genes of the HUFA biosynthesis pathway in fish, and recently we isolated two cDNAs from zebrafish (Danio rerio), one with high similarity to mammalian ∆6 desaturase genes (Hastings et al., 2001) and one with”
- Elongation of long-chain fatty acids in rabbitfish Siganus canaliculatus: Cloning, functional characterisation and tissue distribution of Elovl5- and Elovl4-like elongases (2012, background): “When cultures OD600 reached 1, the expression of the transgene was induced by the addition of galactose to 2% (wt/vol) and the FA substrate added (Hastings et al., 2001).”