The Tumor Suppressor Protein p53 and the Ferroptosis Network
By R. Kang, Guido Kroemer, D. Tang. Free Radical Biology & Medicine, 2018
620 citations recorded by the source corpus.
ABSTRACT Ferroptosis is a form of lipid peroxidation‐induced cell death that can be regulated in many ways, from altering the activity of antioxidant enzymes to the level of transcription factors. The p53 tumor suppressor is 'the guardian of the genome' that participates in the control of cell survival and division under various stresses. Beyond its effects on apoptosis, autophagy, and cell cycle, p53 also regulates ferroptosis either through a transcriptional or posttranslational mechanism. On one hand, p53 can enhance ferroptosis by inhibiting the expression of SLC7A11 (solute carrier family 7 member 11) or by enhancing that of SAT1 (spermidine/spermine N1‐acetyltransferase 1) and GLS2 (glutaminase 2). On the other hand, p53 suppresses ferroptosis through the direct inhibition of DPP4 (dipeptidyl peptidase 4) activity or by the induction of CDKN1A/p21 (cyclin dependent kinase inhibitor 1 A) expression. Here, we review recent discoveries and emerging trends in the study of the ferroptosis network and highlight the context‐dependent impact of p53 on ferroptosis and oxidative stress. Graphical abstract Figure. No Caption available. HighlightsFerroptosis is a form of regulated cell death.p53 plays a dual role in ferroptosis.p53 enhances ferroptosis through targeting SLC7A11, SAT1 or GLS2.p53 suppresses ferroptosis through targeting DPP4 or CDKN1A.Activation of autophagy promotes ferroptosis.
Subfields: Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/5e73315b61b645d6003f1e83552b3b7f6ca417fc
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In Molecular Biology
In Pulmonary and Respiratory Medicine
Citations in the corpus
- Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “Further studies have found that p53 can promote ferroptosis by inhibiting SLC7A11 expression or promoting spermidine/spermine N1‐ acetyltransferase 1 and glutaminase 2 expression.(467) These results further indicate that p53 might be the central link of multiple cell death pathways.”
- Autophagy-Dependent Ferroptosis: Machinery and Regulation (2020, background): “, 2011) and tumor protein p53 [TP53] (Gnanapradeepan et al., 2018; Jiang et al., 2015; Kang et al., 2019; Xie et al., 2017)), heat shock response (Sun et al.”