Oxidative stress and cancer: have we moved forward?

By Barry Halliwell. Biochemical Journal, 2007

1,297 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2775a7fcbc55e93db2de4ebcc539cb58de64e3e4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. J. Kundu
2. Peng Huang
3. Y. Surh
4. J. Alexandre
5. Irina Milisav
6. Dusan Suput
7. Miriama Šimunková
8. M. Valko

In Molecular Biology

1. J. Kundu
2. Subash C. Gupta
3. Bharat B. Aggarwal
4. K. Jomová
5. M. Valko
6. Y. Surh
7. D. Trachootham
8. Peng Huang

Citations in the corpus

• Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants (2013, background): “Both “antioxidative” and oxidative stresses leading to the antioxidative imbalance can be damaging for the organism and can result in cancerogenesis [33] and aging (Figures 2 and 3).”
• Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? (2009, background): “Although in some studies the observed increase of oxidative stress might be due to sample handling, analytical artefacts or cell-culture condition”
• Antioxidant and Anti‐Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models (2015, background): “Oxidative damage has been implicated in many pathological conditions, including cardiovascular diseases and cancer (Halliwell, 2007; Reuter et al., 2010).”
• The oxidative stress hypothesis in Alzheimer's disease. (2013, background): “Moreover, it is known that increased oxidative stress is associated with the development of neoplasms (Halliwell & Gutteridge 2007, Halliwell 2007, Reuter et al. 2010).”
• Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “However, paradoxically high concentrations of ROS can trigger apoptotic or necrotic cell death [194-196].”
• Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “amount of ROS is required for tumor promotion, an excessive level serves to suppress tumors (113, 334).”
• Oxidative stress, DNA methylation and carcinogenesis. (2008, background): “The cellular and molecular events underlying each of these phases include DNA damage, increased proliferation, deficient cell death and further genetic instability, respectively [1,4].”
• Inflammation: gearing the journey to cancer. (2008, background): “Paradoxically, ROS and RNS can cause apoptotic or necrotic cell death [36,37].”
• Targeting Free Radicals in Oxidative Stress-Related Human Diseases. (2017, background): “It is known that ROS can both initiate cancer and contribute to its progression [13].”