The oxidative stress hypothesis in Alzheimer's disease.
By M. Pădurariu, A. Ciobîcă, R. Lefter, I. Șerban, C. Ștefănescu, R. Chiriță. Psychiatria Danubina, 2013
737 citations recorded by the source corpus.
Oxidative stress may be involved in many somatic and psychiatric pathological states including dementia. The hypothesis of oxidative stress involvement in dementia is supported by much scientific data through biochemical, genetic and molecular studies. Thus, there are many reports of an increased level of the markers for oxidative damage, alterations in the specific activity of the antioxidant system, mutations in specific genes, mitochondrial disturbances and also several connections between oxidative stress and amyloid plaques. Despite these evidence and clinical approaches in using antioxidant therapy in dementia treatment, studies have failed to prove a clear benefit for antioxidant treatment in dementia. Hence, there is a need for further research regarding antioxidant therapy in very early stages of dementia.
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Citations in the corpus
- Oxidative Stress, Prooxidants, and Antioxidants: The Interplay (2014, background): “For instance, oxidation of nucleic acid and protein along with peroxidation of lipid is highest and most severe in the hippocampus of the brain, which is involved in the processing of memory along with cognitive function [158, 159].”
- Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies (2024, background): “191,193 – 195 The abnormality of the electron transport chain within mitochondria is particularly a signi fi cant contributor to free radical production.”
- Role of oxidative stress in Alzheimer's disease (2016, background): “Their double binds allow the removal of hydrogen ions (58) and increased lipid peroxidation, which is the most prominent feature in which degenerative change is most pronounced in the AD brain (59).”
- Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease (2017, background): “While compelling evidence implicates oxidative stress in the early molecular mechanisms of AD [180], there is no FDA-approved antioxidant therapy for AD.”