Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

By Jens Derbinski, Antje Schulte, B. Kyewski, L. Klein. Nature Immunology, 2001

1,146 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/265e22ba7990e51a89f18daa7e0bdb9d5a40d8ef

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In Immunology

1. H. von Boehmer
2. V. Kuchroo
3. I. Apostolou
4. Alexander Y. Rudensky
5. D. Mathis
6. A. Abbas
7. L. Klein
8. L. Walker

Citations in the corpus

• Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells (2007, background): “A separate line of experiments has firmly established that mTECs contribute to T cell tolerance by 'promiscuously' expressing a wide range of otherwise tissue-specific antigen”
• The enemy within: keeping self-reactive T cells at bay in the periphery (2002, background): “Although recent data indicate that many tissue-specific antigens are represented (at least at the messenger RNA level) in the thymu”
• Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo (2003, background): “However, mounting evidence suggests that so-called “tissue-specific” promoters, including that of the insulin gene, are in fact active in the thymus (12, 28).”
• Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis (2003, background): “Although MOG protein expression has not been detected in the thymus (29), the presence of MOG mRNA has been reported in a subpopulation of medullary thymic epithelial cells (30).”
• Origin of regulatory T cells with known specificity for antigen (2002, background): “The “aberrant” or “promiscuous” expression of HA in thymic epithelial cells, which may reflect the general promiscuous expression pattern of tissue-specific antigens in thymic epithelial cell”
• The cellular mechanism of Aire control of T cell tolerance. (2005, background): “MECs are rather rare, constituting only a few percent of thymic stromal cells (reviewed in Boyd et al., 1993); worse, it has been suggested that at any given time any given peripheral-tissue transcript may be expressed by only a fraction (as low as 0.5%) of thymic MECs ( Derbinski et al., 2001 ).”