Cytokine activation induces human memory-like NK cells.

By R. Romee, Stephanie E. Schneider, Jeffrey W. Leong, Julie M. Chase, Catherine R. Keppel, R. Sullivan, M. Cooper, T. Fehniger. 2012

629 citations recorded by the source corpus.

Subfields: Immunology

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Citations in the corpus

• Pre-activation with IL-12, IL-15, and IL-18 induces CD25 and a functional high affinity IL-2 receptor on human cytokine-induced memory-like NK cells (2014, methodology): “In these experiments, purified NK cells were preactivated with cytokine combinations that result in CIML NK cells [20] and CD25 induction (IL-12 plus IL-18 or IL-15 plus IL-18) for 16 hours, washed, and then rested for 2 days in cytokine-free media to allow the NK cells to return to a baseline state”
• CAR-NK cells: A promising cellular immunotherapy for cancer (2020, background): “[92,93] Data from the Phase I clinical trial demonstrated that the cytokine-induced memory-like NK cells exhibited enhanced expansion and robust anti-leukaemia responses in AML patients after adoptive transfer, [92] suggesting that introduction of CAR into these memory-like NK cells could be a promi”
• The broad spectrum of human natural killer cell diversity (2017, background): “However, a number of mouse and human studies have highlighted the potential for NK cells to form immunological memory and differentiate into specialized memory-like cells now commonly referred to as adaptive NK cells (Cooper et al., 2009; O’Leary et al., 2006; Romee et al., 2012; Sun et al., 2009).”
• Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia (2016, methodology): “Flow cytometric analysis Cell staining was performed as described (18, 19, 35), and data were acquired on a Gallios flow cytometer (Beckman Coulter) and analyzed using Kaluza (Beckman Coulter) or FlowJo (Tree Star) software.”
• The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy (2017, background): “Similarly, human cytokine-induced memory NK cells with longterm effector response have been reported in response to IL-12, IL-15, and IL-18 stimulation (123).”
• Intraepithelial type 1 innate lymphoid cells are a unique subset of cytokine responsive interferon-γ-producing cells (2013, neutral): “It will be important to 10 Immunity 38, 1–13, April 18, 2013 ª2013 Elsevier Inc. explore the relationship between intraepithelial ILC1 and the recently reported memory NK cells (Cooper et al., 2009; Romee et al., 2012; Sun and Lanier, 2011).”