TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

By S. Viel, A. Marçais, F. Guimarães, Roisín M Loftus, Jessica Rabilloud, Morgan Grau, Sophie Degouve, S. Djebali, Amélien Sanlaville, E. Charrier and 10 more. Science Signaling, 2016

606 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/24a7c4c61b23f2f57f19dbb2f71f31ee6aa0f51c

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In Immunology

1. J. Massagué
2. E. Batlle

Citations in the corpus

• Transforming Grown Factor-β Signaling in Immunity and Cancer (2019, positive): “This study also reveal that TGF-β-mediated suppression of NK activity is due to impairment of mTOR metabolic signaling downstream of stimulatory cytokines such as IL15 (Viel et al., 2016).”
• Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “[196] reported that TGF-β1 selectively downregulated NKp30, NKp46, NKG2D and DNAM-1 expression in vitro through the activation of the SMAD2/3-dependent signaling pathway.”