Targeting natural killer cells in cancer immunotherapy

By Camille Guillerey, Nicholas D. Huntington, M. Smyth. Nature Immunology, 2016

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Mechanisms of resistance to immune checkpoint inhibitors (2018, background): “HLA-independent tumour killing via natural killer cells (e.g., anti-KIR) (Guillerey et al, 2016) may be an option in tumours in which HLA neoantigen presentation is insufficient to promote cytotoxic T-cell killing.”
Natural killer cells in cancer biology and therapy (2020, background): “In addition, as documented in multiple models and experiments, NK cells could distinguish abnormal cells from healthy ones, leading to more specific anti-tumor cytotoxicity and reduced off-target complications [9, 10].”
NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control (2018, background): “This might be expected from the fact that NK cells can directly kill tumor cells and produce cytokines with anti-tumor effects (Guillerey et al., 2016).”