Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
By R. Zimmermann, J. Strauss, G. Haemmerle, Gabriele Schoiswohl, R. Birner‐Gruenberger, M. Riederer, A. Lass, Georg Neuberger, Frank Eisenhaber, A. Hermetter and 1 more. Science, 2004
2,122 citations recorded by the source corpus.
Subfields: Biochemistry, Cell Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/25110019e980f8906a0525318ee59175b24fc783
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Citations in the corpus
- Non Alcoholic Fatty Liver Disease, Hepatic Insulin Resistance and Type 2 Diabetes (2014, background): “This seemingly paradoxical effect could be explained by a specific compartmentation pattern of DAGs.”
- Effect of dietary bile acids on growth, body composition, lipid metabolism and microbiota in grass carp (Ctenopharyngodon idella) (2018, background): “…index 5.77 4.90 4.09 Simpson index 0.03 0.08 0.12 OTU, operational taxonomic unit. a diglyceride and a free fatty acid (Smirnova et al., 2006); then, HSL catalyses the diglyceride into a mono- glyceride and a free fatty acid (Watt & Steinberg, 2008; Zhu et al., 2007; Zimmermann et al., 2004).”
- Growth and Lipid Metabolism of the Pacific White Shrimp Litopenaeus vannamei at Different Salinities (2014, background): “…mobilization has increased, because ATGL (TAG hydrolysis), LPL, and HSL are crucial enzymes in lipid mobilization by performing the first step in hydrolyzing TAG to generate diacylglycerol and free fatty acid (Osuga et al. 2000, Jenkins et al. 2004, Villena et al. 2004, Zimmermann et al. 2004).”
- Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. (2006, background): “Phosphorylation activates HSL and also promotes the interaction of perilipins (particularly perilipin A) with HSL.”
- Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. (2005, background): “glyceride lipase (ATGL) (Zimmermann et al., 2004), have been”
- Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes (2008, background): “A second enzyme, adipose triglyceride lipase ( ATGL ), also participates in fat mobilizatio”
- FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling (2012, background): “The enzyme, first described in 2004 (Jenkins et al., 2004; Villena et al., 2004; Zimmermann et al., 2004), belongs to the family patatin domain-containing proteins including nine human and eight murine members.”
- Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores (2011, background): “In contrast to ATGL deficiency, hormone-sensitive lipase (HSL)deficient mice do not show increased fat deposition, are not overweight or obese, and lose WAT mass with increasing age [11,12,19,20].”
- PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores (2009, background): “ATGL catalyzes the initial step in lipolysis (TAG to diacylglycerol), while HSL catalyzes the second step (diacylglycerol to monoacylglycerol), and a soluble monoglyceride lipase catalyzes release of the remaining fatty acyl moiety from the glycerol backbone [50,51].”
- Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. (2006, methodology): “The drastic impairment of fat cell lipolysis in ATGL inhibition studies in vitro (Zimmermann et al., 2004; Smirnova et al., 2006) as well as the nutritional and insulin dependent regulation of ATGL gene expression in adipose tissue of mice (Villena et al., 2004; Kershaw et al., 2006) implied a key…”