FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

By R. Zechner, R. Zimmermann, Thomas O. Eichmann, S. Kohlwein, G. Haemmerle, A. Lass, Frank Madeo. Cell Metabolism, 2012

1,077 citations recorded by the source corpus.

Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets. Recent discoveries of essential lipolytic enzymes and characterization of numerous regulatory proteins and mechanisms have fundamentally changed our perception of lipolysis and its impact on cellular metabolism. New findings that lipolytic products and intermediates participate in cellular signaling processes and that “lipolytic signaling” is particularly important in many nonadipose tissues unveil a previously underappreciated aspect of lipolysis, which may be relevant for human disease.

Subfields: Biochemistry, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/7aea88b83ad7822d5f213efecaacb1e34a14c309

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Erika L. Pearce
2. Edward J. Pearce

In Physiology

1. Erika L. Pearce
2. Edward J. Pearce
3. Michael D. Buck

In Surgery

1. Erika L. Pearce
2. Michael D. Buck

Citations in the corpus

• Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development (2014, background): “Lipolysis is the hydrolysis of stored lipids to liberate FA that can then be used as energy substrates, essential precursors for membrane synthesis, or signaling mediators (Farese and Walther, 2009; Lass et al., 2011; Zechner et al., 2012).”